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HES1 oxysterol-binding protein related protein HES1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854412, updated on 29-Jun-2024

Summary

Gene symbol
HES1
Gene description
oxysterol-binding protein related protein HES1
Primary source
FungiDB:YOR237W
Locus tag
YOR237W
See related
SGD:S000005763; AllianceGenome:SGD:S000005763; VEuPathDB:YOR237W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
OSH5
Summary
Enables oxysterol binding activity and sterol transfer activity. Involved in several processes, including maintenance of cell polarity; piecemeal microautophagy of the nucleus; and sterol transport. Located in cellular bud neck and fungal-type vacuole membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See HES1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (781994..783298)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Irc13p Neighboring gene ncRNA Neighboring gene dihydrofolate reductase Neighboring gene uncharacterized protein Neighboring gene tRNA(Thr) (cytosine(32)-N(3))-methyltransferase

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables lipid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables oxysterol binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables oxysterol binding IDA
Inferred from Direct Assay
more info
PubMed 
enables oxysterol binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables sterol transfer activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sterol transfer activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in endocytosis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in exocytosis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in maintenance of cell polarity IEA
Inferred from Electronic Annotation
more info
 
involved_in maintenance of cell polarity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in piecemeal microautophagy of the nucleus IEA
Inferred from Electronic Annotation
more info
 
involved_in piecemeal microautophagy of the nucleus IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in sterol transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sterol transport IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in sterol transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cellular bud neck HDA PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
 
located_in vacuole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
oxysterol-binding protein related protein HES1
NP_014880.3
  • Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP); SWAT-GFP and mCherry fusion proteins localize to the bud neck and vacuolar membrane; HES1 has a paralog, KES1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    781994..783298
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183656.3NP_014880.3  TPA: oxysterol-binding protein related protein HES1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014880.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2U0, P35843
    UniProtKB/TrEMBL
    A0A8H4BX72, B3LJQ8, C7GWE9, N1NX89
    Conserved Domains (1) summary
    pfam01237
    Location:12365
    Oxysterol_BP; Oxysterol-binding protein