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HELZ2 helicase with zinc finger 2 [ Homo sapiens (human) ]

Gene ID: 85441, updated on 13-Mar-2020

Summary

Official Symbol
HELZ2provided by HGNC
Official Full Name
helicase with zinc finger 2provided by HGNC
Primary source
HGNC:HGNC:30021
See related
Ensembl:ENSG00000130589 MIM:611265
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDIP-1; PRIC285
Summary
The protein encoded by this gene is a nuclear transcriptional co-activator for peroxisome proliferator activated receptor alpha. The encoded protein contains a zinc finger and is a helicase that appears to be part of the peroxisome proliferator activated receptor alpha interacting complex. This gene is a member of the DNA2/NAM7 helicase gene family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in spleen (RPKM 6.7), bone marrow (RPKM 5.2) and 25 other tissues See more
Orthologs

Genomic context

See HELZ2 in Genome Data Viewer
Location:
20q13.33
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (63558086..63574239, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62189439..62205592, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites Neighboring gene Sharpr-MPRA regulatory region 13995 Neighboring gene fibronectin type III domain containing 11 Neighboring gene glucocorticoid modulatory element binding protein 2 Neighboring gene melanoma highly expressed competing endogenous lncRNA for miR-425 and miR-489

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ00244, KIAA1769, MGC132634, MGC138228

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nuclear receptor transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribonuclease activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of lipid metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
helicase with zinc finger domain 2
Names
ATP-dependent helicase PRIC285
PDIP1
PPAR gamma DBD-interacting protein 1
PPAR-alpha-interacting complex protein 285
PPAR-gamma DNA-binding domain-interacting protein 1
PPARG-DBD-interacting protein 1
PPARgamma-DNA-binding domain-interacting protein1
PRIC complex
helicase with zinc finger 2, transcriptional coactivator
peroxisomal proliferator-activated receptor A interacting complex 285
peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein
peroxisomal proliferator-activated receptor alpha-interacting cofactor complex, 285 kD subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037335.2NP_001032412.2  helicase with zinc finger domain 2 isoform 1

    See identical proteins and their annotated locations for NP_001032412.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB201715, AK074171, AL121829
    Consensus CDS
    CCDS33508.1
    UniProtKB/Swiss-Prot
    Q9BYK8
    Related
    ENSP00000417401.1, ENST00000467148.1
    Conserved Domains (6) summary
    cd00009
    Location:519590
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    smart00955
    Location:13341693
    RNB; This domain is the catalytic domain of ribonuclease II
    COG1112
    Location:642938
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam13086
    Location:21522399
    AAA_11; AAA domain
    pfam13087
    Location:24062611
    AAA_12; AAA domain
    cl22977
    Location:715915
    UvrD_C_2; UvrD-like helicase C-terminal domain
  2. NM_033405.3NP_208384.3  helicase with zinc finger domain 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs at the 5' end compared to variant 1. It encodes isoform 2, which has a shorter, distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK074171, AL121829
    Consensus CDS
    CCDS13527.1
    UniProtKB/Swiss-Prot
    Q9BYK8
    Related
    ENSP00000393257.2, ENST00000427522.6
    Conserved Domains (5) summary
    smart00955
    Location:7651124
    RNB; This domain is the catalytic domain of ribonuclease II
    COG1112
    Location:73369
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam13086
    Location:15831830
    AAA_11; AAA domain
    pfam13087
    Location:18372042
    AAA_12; AAA domain
    cl22977
    Location:146346
    UvrD_C_2; UvrD-like helicase C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    63558086..63574239 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452007.1XP_024307775.1  helicase with zinc finger domain 2 isoform X2

    Conserved Domains (6) summary
    smart00451
    Location:3969
    ZnF_U1; U1-like zinc finger
    smart00955
    Location:13341693
    RNB; This domain is the catalytic domain of ribonuclease II
    pfam13086
    Location:21522399
    AAA_11; AAA domain
    pfam13087
    Location:24062636
    AAA_12; AAA domain
    cl22977
    Location:715915
    UvrD_C_2; UvrD-like helicase C-terminal domain
    cl26261
    Location:541705
    AAA_11; AAA domain
  2. XM_024452006.1XP_024307774.1  helicase with zinc finger domain 2 isoform X1

    Conserved Domains (6) summary
    smart00451
    Location:3969
    ZnF_U1; U1-like zinc finger
    smart00955
    Location:13341693
    RNB; This domain is the catalytic domain of ribonuclease II
    pfam13086
    Location:21802427
    AAA_11; AAA domain
    pfam13087
    Location:24342639
    AAA_12; AAA domain
    cl22977
    Location:715915
    UvrD_C_2; UvrD-like helicase C-terminal domain
    cl26261
    Location:541705
    AAA_11; AAA domain
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