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KIN4 putative serine/threonine protein kinase KIN4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854408, updated on 18-Sep-2024

Summary

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Official Symbol
KIN4
Official Full Name
putative serine/threonine protein kinase KIN4
Primary source
SGD:S000005759
Locus tag
YOR233W
See related
AllianceGenome:SGD:S000005759; FungiDB:YOR233W; VEuPathDB:YOR233W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
KIN3; KIN31
Summary
Enables protein serine/threonine kinase activity. Involved in mitotic spindle orientation checkpoint signaling and protein localization to spindle pole body. Located in cell cortex; cellular bud neck; and spindle pole body. Orthologous to human HUNK (hormonally up-regulated Neu-associated kinase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See KIN4 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (775846..778248)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase MKK1 Neighboring gene Mge1p Neighboring gene ribosomal 60S subunit protein L33B Neighboring gene Irc13p Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and genetic analysis of the gene encoding a new protein kinase in Saccharomyces cerevisiae. Kambouris NG, et al. Yeast, 1993 Feb. PMID 8465601
  2. Lte1 promotes mitotic exit by controlling the localization of the spindle position checkpoint kinase Kin4. Falk JE, et al. Proc Natl Acad Sci U S A, 2011 Aug 2. PMID 21709215, Free PMC Article
  3. Sequence and analysis of a 26.9 kb fragment from chromosome XV of the yeast Saccharomyces cerevisiae. Boyer J, et al. Yeast, 1996 Dec. PMID 8972580
  4. The 14-3-3 protein Bmh1 functions in the spindle position checkpoint by breaking Bfa1 asymmetry at yeast centrosomes. Caydasi AK, et al. Mol Biol Cell, 2014 Jul 15. PMID 24850890, Free PMC Article
  5. Cdc5-dependent asymmetric localization of bfa1 fine-tunes timely mitotic exit. Kim J, et al. PLoS Genet, 2012 Jan. PMID 22253605, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Spindle Position Checkpoint Kinase Kin4 Regulates Organelle Transport in Saccharomyces cerevisiae.
    Title: Spindle Position Checkpoint Kinase Kin4 Regulates Organelle Transport in Saccharomyces cerevisiae.
  2. Data show that bud-localized MEN regulator Lte1 prevents Kin4 that escapes into the bud from associating with SPBs in the daughter cell.
    Title: Lte1 promotes mitotic exit by controlling the localization of the spindle position checkpoint kinase Kin4.
  3. Data suggest that Lte1 promotes mitotic exit by inhibiting Kin4 activity at the daughter spindle pole body.
    Title: The cortical protein Lte1 promotes mitotic exit by inhibiting the spindle position checkpoint kinase Kin4.
  4. The bud neck-associated kinase Elm1 participates in Kin4 activation and SPOC signaling by phosphorylating a conserved residue within the activation loop of Kin4.
    Title: Elm1 kinase activates the spindle position checkpoint kinase Kin4.
  5. show that the protein phosphatase functions upstream of Kin4, regulating the kinase's phosphorylation and localization during an unperturbed cell cycle and during SPOC activation, thus defining the phosphatase as a key regulator of SPOC function
    Title: The protein phosphatase 2A functions in the spindle position checkpoint by regulating the checkpoint kinase Kin4.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity HDA PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic spindle orientation checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within peroxisome inheritance IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within peroxisome inheritance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to spindle pole body IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vacuole inheritance IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
putative serine/threonine protein kinase KIN4
NP_014876.1
  • Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint (SPOC) is activated; regulates peroxisomal transport and vacuolar inheritance along with Frk1p; protects the peroxisomal Myo2p receptor Inp2p from degradation in mother cells along with Frk1p; localizes asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    775846..778248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183652.1 → NP_014876.1  TPA: putative serine/threonine protein kinase KIN4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014876.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2T7, Q01919
    UniProtKB/TrEMBL
    A6ZP74, B3LJQ5, B5VSB4, C7GWF1, C8ZGY7, N1NWU2
    Conserved Domains (1) summary
    cd14076
    Location:44 → 313
    STKc_Kin4; Catalytic domain of the yeast Serine/Threonine Kinase, Kin4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01919.1

Gene LinkOut

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