U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

KIN4 putative serine/threonine protein kinase KIN4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854408, updated on 8-Feb-2025

Summary

Official Symbol
KIN4
Official Full Name
putative serine/threonine protein kinase KIN4
Primary source
SGD:S000005759
Locus tag
YOR233W
See related
AllianceGenome:SGD:S000005759; FungiDB:YOR233W; VEuPathDB:YOR233W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
KIN3; KIN31
Summary
Enables protein serine/threonine kinase activity. Involved in mitotic spindle orientation checkpoint signaling and protein localization to spindle pole body. Acts upstream of or within peroxisome inheritance and vacuole inheritance. Located in cell cortex; cellular bud neck; and spindle pole body. Human ortholog(s) of this gene implicated in anencephaly and uterine fibroid. Orthologous to human NUAK1 (NUAK family kinase 1) and NUAK2 (NUAK family kinase 2). [provided by Alliance of Genome Resources, Feb 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See KIN4 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (775846..778248)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase MKK1 Neighboring gene Mge1p Neighboring gene ribosomal 60S subunit protein L33B Neighboring gene Irc13p Neighboring gene ncRNA

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity HDA PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle pole body IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
putative serine/threonine protein kinase KIN4
NP_014876.1
  • Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint (SPOC) is activated; regulates peroxisomal transport and vacuolar inheritance along with Frk1p; protects the peroxisomal Myo2p receptor Inp2p from degradation in mother cells along with Frk1p; localizes asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    775846..778248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183652.1NP_014876.1  TPA: putative serine/threonine protein kinase KIN4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014876.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2T7, Q01919
    UniProtKB/TrEMBL
    A6ZP74, B3LJQ5, B5VSB4, C7GWF1, C8ZGY7, N1NWU2
    Conserved Domains (1) summary
    cd14076
    Location:44313
    STKc_Kin4; Catalytic domain of the yeast Serine/Threonine Kinase, Kin4