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MGE1 Mge1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854407, updated on 8-Sep-2022

Summary

Gene symbol
MGE1
Gene description
Mge1p
Primary source
SGD:S000005758
Locus tag
YOR232W
See related
AllianceGenome:SGD:S000005758
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YGE1
Summary
Enables adenyl-nucleotide exchange factor activity. Involved in protein import into mitochondrial matrix and protein refolding. Located in mitochondrial matrix. Part of PAM complex, Tim23 associated import motor. Orthologous to several human genes including GRPEL1 (GrpE like 1, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See MGE1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (774573..775259)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene transcriptional modulator Neighboring gene mitogen-activated protein kinase kinase MKK1 Neighboring gene putative serine/threonine protein kinase KIN4 Neighboring gene ribosomal 60S subunit protein L33B

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the MGE1 gene: The MGE1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, S.pombe, M.oryzae, N.crassa, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables adenyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables adenyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables adenyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
enables adenyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables chaperone binding IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
 
involved_in protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein import into mitochondrial matrix IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein refolding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of PAM complex, Tim23 associated import motor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of PAM complex, Tim23 associated import motor IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Mge1p
NP_014875.3
  • Mitochondrial matrix cochaperone; nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; acts as oxidative sensor to regulate mitochondrial Ssc1p; in presence of oxidative stress, dimeric Mge1p becomes a monomer and unable to regulate Ssc1p function; homolog of E. coli GrpE and human Mge1 (GRPEL1), which also responds to oxidative stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    774573..775259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183651.3NP_014875.3  TPA: Mge1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014875.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2T6, P38523
    UniProtKB/TrEMBL
    A0A0L8VH09, A0A8H4BXB3, A6ZP73, B3LJQ4, B5VSB3, N1NYQ1
    Conserved Domains (1) summary
    cd00446
    Location:83222
    GrpE; nucleotide exchange factor GrpE