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WTM2 transcriptional modulator [ Saccharomyces cerevisiae S288C ]

Gene ID: 854404, updated on 30-Jul-2025
Official Symbol
WTM2
Official Full Name
transcriptional modulator
Primary source
SGD:S000005755
Locus tag
YOR229W
See related
AllianceGenome:SGD:S000005755; FungiDB:YOR229W; VEuPathDB:YOR229W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and transcription corepressor activity. Involved in several processes, including DNA damage response; negative regulation of silent mating-type cassette heterochromatin formation; and regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (768409..769812)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Her1p Neighboring gene Mcp1p Neighboring gene transcriptional modulator Neighboring gene mitogen-activated protein kinase kinase MKK1

Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Characterization of the Wtm proteins, a novel family of Saccharomyces cerevisiae transcriptional modulators with roles in meiotic regulation and silencing. Pemberton LF, et al. Mol Cell Biol, 1997 Aug. PMID 9234739, Free PMC Article
  2. The WTM genes in budding yeast amplify expression of the stress-inducible gene RNR3. Tringe SG, et al. Genetics, 2006 Nov. PMID 16980392, Free PMC Article
  3. Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein. Zhang Z, et al. Proc Natl Acad Sci U S A, 2006 Jan 31. PMID 16432237, Free PMC Article
  4. Control of ribonucleotide reductase localization through an anchoring mechanism involving Wtm1. Lee YD, et al. Genes Dev, 2006 Feb 1. PMID 16452505, Free PMC Article
  5. The Saccharomyces cerevisiae 14-3-3 proteins Bmh1 and Bmh2 directly influence the DNA damage-dependent functions of Rad53. Usui T, et al. Proc Natl Acad Sci U S A, 2007 Feb 20. PMID 17299042, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic cell cycle IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of silent mating-type cassette heterochromatin formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein-containing complex localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Rpd3L complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Rpd3L-Expanded complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
transcriptional modulator
NP_014872.1
  • Transcriptional modulator; involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats; relocalizes to the cytosol in response to hypoxia; WTM2 has a paralog, UME1, that arose from the whole genome duplication

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    768409..769812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183648.1 → NP_014872.1  TPA: transcriptional modulator

    See identical proteins and their annotated locations for NP_014872.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2T3, Q12206
    UniProtKB/TrEMBL
    A6ZP70, B3LJQ1, C7GWF5, N1NWT9
    Conserved Domains (2) summary
    sd00039
    Location:251 → 285
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:221 → 383
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12206.1

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