RFC1 replication factor C subunit 1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: RFC1
Gene description: replication factor C subunit 1
Primary source: SGD:S000005743
Locus tag: YOR217W
Gene type: protein coding
RNA name: replication factor C subunit 1
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CDC44

Genomic context

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See RFC1 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (749301..751886)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Data show that ATP binding rates and ATP-dependent conformational changes in replication factor C (RFC) are fast relative to proliferating cell nuclear antigen (PCNA) binding rates.
Title: Kinetic analysis of PCNA clamp binding and release in the clamp loading reaction catalyzed by Saccharomyces cerevisiae replication factor C.
We show that Pol eta is less accurate than other yeast DNA polym and the accessory proteins have little effect on fidelity when bypassing a TT dimer. Accessory proteins participate in pol eta functions, but they do not suppress UV mutagenesis.
Title: Effects of accessory proteins on the bypass of a cis-syn thymine-thymine dimer by Saccharomyces cerevisiae DNA polymerase eta.

Submit: New GeneRIF Correction

Pathways from BioSystems

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Base Excision Repair, organism-specific biosystem (from REACTOME)
Base Excision Repair, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle, organism-specific biosystem (from REACTOME)
Cell Cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
Cell Cycle, Mitotic, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Chromosome Maintenance, organism-specific biosystem (from REACTOME)
Chromosome Maintenance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DNA Damage Bypass, organism-specific biosystem (from REACTOME)
DNA Damage Bypass, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DNA Repair, organism-specific biosystem (from REACTOME)
DNA Repair, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DNA Replication, organism-specific biosystem (from WikiPathways)
DNA Replication, organism-specific biosystemDNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original ...
DNA Replication, organism-specific biosystem (from REACTOME)
DNA Replication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DNA replication, organism-specific biosystem (from KEGG)
DNA replication, organism-specific biosystemA complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (D...
DNA replication, conserved biosystem (from KEGG)
DNA replication, conserved biosystemA complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (D...
DNA strand elongation, organism-specific biosystem (from REACTOME)
DNA strand elongation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Dual Incision in GG-NER, organism-specific biosystem (from REACTOME)
Dual Incision in GG-NER, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Dual incision in TC-NER, organism-specific biosystem (from REACTOME)
Dual incision in TC-NER, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Extension of Telomeres, organism-specific biosystem (from REACTOME)
Extension of Telomeres, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gap-filling DNA repair synthesis and ligation in GG-NER, organism-specific biosystem (from REACTOME)
Gap-filling DNA repair synthesis and ligation in GG-NER, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gap-filling DNA repair synthesis and ligation in TC-NER, organism-specific biosystem (from REACTOME)
Gap-filling DNA repair synthesis and ligation in TC-NER, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Global Genome Nucleotide Excision Repair (GG-NER), organism-specific biosystem (from REACTOME)
Global Genome Nucleotide Excision Repair (GG-NER), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Lagging Strand Synthesis, organism-specific biosystem (from REACTOME)
Lagging Strand Synthesis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Leading Strand Synthesis, organism-specific biosystem (from REACTOME)
Leading Strand Synthesis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Mismatch repair, organism-specific biosystem (from KEGG)
Mismatch repair, organism-specific biosystemDNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preven...
Mismatch repair, conserved biosystem (from KEGG)
Mismatch repair, conserved biosystemDNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preven...
Nucleotide Excision Repair, organism-specific biosystem (from REACTOME)
Nucleotide Excision Repair, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Nucleotide excision repair, organism-specific biosystem (from KEGG)
Nucleotide excision repair, organism-specific biosystemNucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the ...
Nucleotide excision repair, conserved biosystem (from KEGG)
Nucleotide excision repair, conserved biosystemNucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the ...
PCNA-Dependent Long Patch Base Excision Repair, organism-specific biosystem (from REACTOME)
PCNA-Dependent Long Patch Base Excision Repair, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Polymerase switching, organism-specific biosystem (from REACTOME)
Polymerase switching, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Polymerase switching on the C-strand of the telomere, organism-specific biosystem (from REACTOME)
Polymerase switching on the C-strand of the telomere, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RF-C complex, organism-specific biosystem (from KEGG)
RF-C complex, organism-specific biosystemStructural complex; Genetic information processing; Replication system
RF-C complex, conserved biosystem (from KEGG)
RF-C complex, conserved biosystemStructural complex; Genetic information processing; Replication system
Recognition of DNA damage by PCNA-containing replication complex, organism-specific biosystem (from REACTOME)
Recognition of DNA damage by PCNA-containing replication complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway, organism-specific biosystem (from REACTOME)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Resolution of Abasic Sites (AP sites), organism-specific biosystem (from REACTOME)
Resolution of Abasic Sites (AP sites), organism-specific biosystemcomputationally inferred pathway (not manually curated)
S Phase, organism-specific biosystem (from REACTOME)
S Phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Synthesis of DNA, organism-specific biosystem (from REACTOME)
Synthesis of DNA, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Telomere C-strand (Lagging Strand) Synthesis, organism-specific biosystem (from REACTOME)
Telomere C-strand (Lagging Strand) Synthesis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Telomere Maintenance, organism-specific biosystem (from REACTOME)
Telomere Maintenance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Termination of translesion DNA synthesis, organism-specific biosystem (from REACTOME)
Termination of translesion DNA synthesis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transcription-Coupled Nucleotide Excision Repair (TC-NER), organism-specific biosystem (from REACTOME)
Transcription-Coupled Nucleotide Excision Repair (TC-NER), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Translesion Synthesis by POLH, organism-specific biosystem (from REACTOME)
Translesion Synthesis by POLH, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Translesion synthesis by POLI, organism-specific biosystem (from REACTOME)
Translesion synthesis by POLI, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Translesion synthesis by POLK, organism-specific biosystem (from REACTOME)
Translesion synthesis by POLK, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Translesion synthesis by REV1, organism-specific biosystem (from REACTOME)
Translesion synthesis by REV1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template, organism-specific biosystem (from REACTOME)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the RFC1 gene: The RFC1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, and frog.
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by GO

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to DNA clamp loader activity	IDA Inferred from Direct Assay more info	PubMed
DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
DNA repair	IEA Inferred from Electronic Annotation more info
DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
DNA replication	IEA Inferred from Electronic Annotation more info
cell cycle	IEA Inferred from Electronic Annotation more info
cell division	IEA Inferred from Electronic Annotation more info
leading strand elongation	IDA Inferred from Direct Assay more info	PubMed
mismatch repair	IGI Inferred from Genetic Interaction more info	PubMed
mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
DNA replication factor C complex	IDA Inferred from Direct Assay more info	PubMed
DNA replication factor C complex	IEA Inferred from Electronic Annotation more info
nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: replication factor C subunit 1

NP_014860.1

Subunit of heteropentameric Replication factor C (RF-C); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

749301..751886

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183636.1 → NP_014860.1 TPA: replication factor C subunit 1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014860.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P38630

Conserved Domains (3) summary

COG5275
Location:1 → 277

COG5275; BRCT domain type II [General function prediction only]

pfam08519
Location:621 → 775

RFC1; Replication factor RFC1 C terminal domain

cl25701
Location:298 → 762

RuvB_N; Holliday junction DNA helicase ruvB N-terminus