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SAS5 Sas5p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854388, updated on 2-Nov-2024

Summary

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Official Symbol
SAS5
Official Full Name
Sas5p
Primary source
SGD:S000005739
Locus tag
YOR213C
See related
AllianceGenome:SGD:S000005739; FungiDB:YOR213C; VEuPathDB:YOR213C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables histone acetyltransferase activity. Involved in subtelomeric heterochromatin formation. Located in chromatin. Part of SAS acetyltransferase complex. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 4. Orthologous to human MLLT1 (MLLT1 super elongation complex subunit); MLLT3 (MLLT3 super elongation complex subunit); and YEATS2 (YEATS domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SAS5 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (744535..745281, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene dynamin-related GTPase MGM1 Neighboring gene G protein subunit beta Neighboring gene Spr2p Neighboring gene Aim41p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sas4 and Sas5 are required for the histone acetyltransferase activity of Sas2 in the SAS complex. Sutton A, et al. J Biol Chem, 2003 May 9. PMID 12626510
  2. Identification of SAS4 and SAS5, two genes that regulate silencing in Saccharomyces cerevisiae. Xu EY, et al. Genetics, 1999 Sep. PMID 10471696, Free PMC Article
  3. SAS4 and SAS5 are locus-specific regulators of silencing in Saccharomyces cerevisiae. Xu EY, et al. Genetics, 1999 Sep. PMID 10471697, Free PMC Article
  4. Proliferating cell nuclear antigen (PCNA) is required for cell cycle-regulated silent chromatin on replicated and nonreplicated genes. Miller A, et al. J Biol Chem, 2010 Nov 5. PMID 20813847, Free PMC Article
  5. Nuclear import of the histone acetyltransferase complex SAS-I in Saccharomyces cerevisiae. Schaper S, et al. J Cell Sci, 2005 Apr 1. PMID 15788653

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in subtelomeric heterochromatin formation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of Ino80 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SAS acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SAS acetyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of SWI/SNF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatin IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIF complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Sas5p
NP_014856.1
  • Subunit of the SAS complex (Sas2p, Sas4p, Sas5p); acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    744535..745281 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183632.1 → NP_014856.1  TPA: Sas5p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014856.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2R9, Q99314
    UniProtKB/TrEMBL
    A6ZP56, B3LJN7, C7GWG9, C8ZGW8, N1NWS5
    Conserved Domains (1) summary
    COG5033
    Location:1 → 245
    TFG3; Transcription initiation factor IIF, auxiliary subunit [Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99314.1

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