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RPB10 DNA-directed RNA polymerase core subunit RPB10 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854385, updated on 12-Aug-2025
Official Symbol
RPB10
Official Full Name
DNA-directed RNA polymerase core subunit RPB10
Primary source
SGD:S000005736
Locus tag
YOR210W
See related
AllianceGenome:SGD:S000005736; FungiDB:YOR210W; VEuPathDB:YOR210W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables zinc ion binding activity. Contributes to DNA-directed RNA polymerase activity and RNA-directed RNA polymerase activity. Involved in tRNA transcription by RNA polymerase III; transcription by RNA polymerase I; and transcription by RNA polymerase II. Part of RNA polymerase I complex; RNA polymerase II, core complex; and RNA polymerase III complex. Orthologous to human POLR2L (RNA polymerase II, I and III subunit L). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See RPB10 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (738320..738532)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene tyrosine protein phosphatase PTP2 Neighboring gene nicotinate phosphoribosyltransferase Neighboring gene dynamin-related GTPase MGM1 Neighboring gene G protein subunit beta

Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Mutants in ABC10beta, a conserved subunit shared by all three yeast RNA polymerases, specifically affect RNA polymerase I assembly. Gadal O, et al. J Biol Chem, 1999 Mar 26. PMID 10085073
  2. RNA polymerase II subunit RPB10 is essential for yeast cell viability. Woychik NA, et al. J Biol Chem, 1990 Oct 15. PMID 2211663
  3. [Three regions of Rpb10 mini-subunit of nuclear RNA polymerases are strictly conserved in all eukaryotes]. Shpakovskiĭ GV, et al. Bioorg Khim, 1996 Dec. PMID 9054344
  4. Two additional common subunits, ABC10 alpha and ABC10 beta, are shared by yeast RNA polymerases. Carles C, et al. J Biol Chem, 1991 Dec 15. PMID 1748681
  5. [Molecular evolution and structure of eukaryotic nuclear RNA polymerase subunits in light of the exon-intron organization of their genes]. Shpakovskiĭ GV, et al. Bioorg Khim, 1999 Nov. PMID 10645488

See all (139) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rtr1 is required for Rpb1-Rpb2 assembly of RNAPII and prevents their cytoplasmic clump formation.
    Title: Rtr1 is required for Rpb1-Rpb2 assembly of RNAPII and prevents their cytoplasmic clump formation.
  2. The expression of Rpb10, a small subunit common to RNA polymerases, is modulated by the R3H domain-containing Rbs1 protein and the Upf1 helicase.
    Title: The expression of Rpb10, a small subunit common to RNA polymerases, is modulated by the R3H domain-containing Rbs1 protein and the Upf1 helicase.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA-directed RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to DNA-directed RNA polymerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-directed RNA polymerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-directed RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to RNA-directed RNA polymerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleolar large rRNA transcription by RNA polymerase I IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA transcription by RNA polymerase III IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in termination of RNA polymerase I transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in termination of RNA polymerase III transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase I IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription by RNA polymerase I IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase I IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transcription by RNA polymerase I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription elongation by RNA polymerase I IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription elongation by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation at RNA polymerase I promoter IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation at RNA polymerase III promoter IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase I complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RNA polymerase I complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase I complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of RNA polymerase II, core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase II, core complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RNA polymerase II, core complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase II, core complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase III complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RNA polymerase III complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase III complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
Preferred Names
DNA-directed RNA polymerase core subunit RPB10
NP_014853.3
  • RNA polymerase subunit ABC10-beta; common to RNA polymerases I, II, and III

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    738320..738532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183629.3 → NP_014853.3  TPA: DNA-directed RNA polymerase core subunit RPB10

    See identical proteins and their annotated locations for NP_014853.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2R6, P22139
    UniProtKB/TrEMBL
    A0A0L8VHE1, A0ABF7PIR6, A6ZP53, B3LJN4, C7GWH2, G2WN82, N1P3F6
    Conserved Domains (1) summary
    cl00712
    Location:1 → 70
    RNA_pol_N; RNA polymerases N / 8 kDa subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P22139.2

Gene LinkOut

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