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RET1 DNA-directed RNA polymerase III core subunit RET1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854382, updated on 11-Jun-2025
Official Symbol
RET1
Official Full Name
DNA-directed RNA polymerase III core subunit RET1
Primary source
SGD:S000005733
Locus tag
YOR207C
See related
AllianceGenome:SGD:S000005733; FungiDB:YOR207C; VEuPathDB:YOR207C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PDS2; RPC128; RPC2
Summary
Contributes to DNA-directed RNA polymerase activity. Involved in tRNA transcription by RNA polymerase III. Part of RNA polymerase III complex. Used to study hypomyelinating leukodystrophy. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease and hypomyelinating leukodystrophy 8. Orthologous to human POLR3B (RNA polymerase III subunit B). [provided by Alliance of Genome Resources, Jun 2025]
Orthologs
all
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See RET1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (730008..733457, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Gep3p Neighboring gene mRNA-binding ribosome synthesis protein NOC2 Neighboring gene tyrosine protein phosphatase PTP2 Neighboring gene nicotinate phosphoribosyltransferase

Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The RET1 gene of yeast encodes the second-largest subunit of RNA polymerase III. Structural analysis of the wild-type and ret1-1 mutant alleles. James P, et al. J Biol Chem, 1991 Mar 25. PMID 2005101
  2. ret1-1, a yeast mutant affecting transcription termination by RNA polymerase III. James P, et al. Genetics, 1990 Jun. PMID 2199311, Free PMC Article
  3. Coordinated nuclear import of RNA polymerase III subunits. Hardeland U, et al. Traffic, 2006 Apr. PMID 16536744
  4. Termination-altering mutations in the second-largest subunit of yeast RNA polymerase III. Shaaban SA, et al. Mol Cell Biol, 1995 Mar. PMID 7862140, Free PMC Article
  5. Mutational analysis of the hydrolytic activity of yeast RNA polymerase III. Bobkova EV, et al. J Biol Chem, 1999 Jul 23. PMID 10409694

See all (103) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Yeast Bud27 modulates the biogenesis of Rpc128 and Rpc160 subunits and the assembly of RNA polymerase III.
    Title: Yeast Bud27 modulates the biogenesis of Rpc128 and Rpc160 subunits and the assembly of RNA polymerase III.
  2. the properties of the corresponding RNAPII (Rpb2-832GYNQED837) and RNAPIII (Rpc128-764GYDIED769) loops by a local mutagenesis of their invariant carboxyl acids.
    Title: Crucial role of a dicarboxylic motif in the catalytic center of yeast RNA polymerases.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA-directed RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to DNA-directed RNA polymerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-directed RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribonucleoside binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated transcription initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA transcription by RNA polymerase III IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in termination of RNA polymerase III transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase III complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
DNA-directed RNA polymerase III core subunit RET1
NP_014850.1
  • Second-largest subunit of RNA polymerase III; RNA polymerase III is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    730008..733457 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183626.1 → NP_014850.1  TPA: DNA-directed RNA polymerase III core subunit RET1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014850.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2R3, P22276, Q12696
    UniProtKB/TrEMBL
    A6ZP50, C7GWH5, C8ZGW3, G2WN79, N1NX57
    Conserved Domains (1) summary
    COG0085
    Location:26 → 1147
    RpoB; DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P22276.2

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