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RET1 DNA-directed RNA polymerase III core subunit RET1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854382, updated on 11-Jun-2025
Official Symbol
RET1
Official Full Name
DNA-directed RNA polymerase III core subunit RET1
Primary source
SGD:S000005733
Locus tag
YOR207C
See related
AllianceGenome:SGD:S000005733; FungiDB:YOR207C; VEuPathDB:YOR207C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PDS2; RPC128; RPC2
Summary
Contributes to DNA-directed RNA polymerase activity. Involved in tRNA transcription by RNA polymerase III. Part of RNA polymerase III complex. Used to study hypomyelinating leukodystrophy. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease and hypomyelinating leukodystrophy 8. Orthologous to human POLR3B (RNA polymerase III subunit B). [provided by Alliance of Genome Resources, Jun 2025]
Orthologs
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See RET1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (730008..733457, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Gep3p Neighboring gene mRNA-binding ribosome synthesis protein NOC2 Neighboring gene tyrosine protein phosphatase PTP2 Neighboring gene nicotinate phosphoribosyltransferase

Genomic Sequence:
NC_001147.6
Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to DNA-directed RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to DNA-directed RNA polymerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-directed RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ribonucleoside binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
 
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of RNA polymerase III complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
DNA-directed RNA polymerase III core subunit RET1
NP_014850.1
  • Second-largest subunit of RNA polymerase III; RNA polymerase III is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    730008..733457 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183626.1NP_014850.1  TPA: DNA-directed RNA polymerase III core subunit RET1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014850.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2R3, P22276, Q12696
    UniProtKB/TrEMBL
    A6ZP50, C7GWH5, C8ZGW3, G2WN79, N1NX57
    Conserved Domains (1) summary
    COG0085
    Location:261147
    RpoB; DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]