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HIS3 imidazoleglycerol-phosphate dehydratase HIS3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854377, updated on 3-May-2025
Official Symbol
HIS3
Official Full Name
imidazoleglycerol-phosphate dehydratase HIS3
Primary source
SGD:S000005728
Locus tag
YOR202W
See related
AllianceGenome:SGD:S000005728; FungiDB:YOR202W; VEuPathDB:YOR202W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HIS10; HIS8
Summary
Enables imidazoleglycerol-phosphate dehydratase activity. Involved in L-histidine biosynthetic process. [provided by Alliance of Genome Resources, May 2025]
Orthologs
all
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See HIS3 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (721946..722608)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Bfr1p Neighboring gene Mrm1p Neighboring gene DEAD-box ATP-dependent RNA helicase DED1 Neighboring gene Gep3p

Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Production of a functional eukaryotic enzyme in Escherichia coli: cloning and expression of the yeast structural gene for imidazole-glycerolphosphate dehydratase (his3). Struhl K, et al. Proc Natl Acad Sci U S A, 1977 Dec. PMID 341150, Free PMC Article
  2. Cloning and functional verification of the Candida milleri HIS3 gene encoding imidazoleglycerol phosphate dehydratase. Park EH, et al. J Microbiol Biotechnol, 2012 Oct. PMID 23075797
  3. Purification and characterization of the imidazoleglycerol-phosphate dehydratase of Saccharomyces cerevisiae from recombinant Escherichia coli. Hawkes TR, et al. Biochem J, 1995 Mar 1. PMID 7887893, Free PMC Article
  4. Sequence and organization analyses of a Zygosaccharomyces rouxii DNA fragment containing the HIS3 gene. Sychrova H, et al. Yeast, 2000 May. PMID 10806420
  5. Promoter elements, regulatory elements, and chromatin structure of the yeast his3 gene. Struhl K. Cold Spring Harb Symp Quant Biol, 1983. PMID 6305590

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The structure of Sc_IGPD reveals that a 24-amino acid insertion forms an extended loop region on the enzyme surface that lies adjacent to the active site, forming interactions with the substrate/inhibitor binding loop that may influence inhibitor potency.
    Title: Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM.
  2. Snf1 protein is important for HIS3 expression
    Title: Histone H3 Ser10 phosphorylation-independent function of Snf1 and Reg1 proteins rescues a gcn5- mutant in HIS3 expression.
  3. We propose that Gcn4p stimulates nucleosome mobilization over the entire HIS3 gene by the SWI/SNF complex. We suggest that the net effect of interplay among remodeling machines at HIS3 is to create a highly dynamic chromatin structure.
    Title: Activation of Saccharomyces cerevisiae HIS3 results in Gcn4p-dependent, SWI/SNF-dependent mobilization of nucleosomes over the entire gene.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables imidazoleglycerol-phosphate dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables imidazoleglycerol-phosphate dehydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables imidazoleglycerol-phosphate dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables imidazoleglycerol-phosphate dehydratase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-histidine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-histidine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within L-histidine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-histidine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
Preferred Names
imidazoleglycerol-phosphate dehydratase HIS3
NP_014845.1
  • Imidazoleglycerol-phosphate dehydratase; catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    721946..722608
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183621.1 → NP_014845.1  TPA: imidazoleglycerol-phosphate dehydratase HIS3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014845.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2Q9, P06633, Q12695, Q70D78, Q70D79, Q70D81, Q70D83
    UniProtKB/TrEMBL
    A6ZP46, B5VS85, C7GWH9, C8ZGV8, G2WN75, N1NYM2
    Conserved Domains (1) summary
    COG0131
    Location:1 → 219
    HisB2; Imidazoleglycerol phosphate dehydratase HisB [Amino acid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06633.2

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