U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZCRB1 zinc finger CCHC-type and RNA binding motif containing 1 [ Homo sapiens (human) ]

Gene ID: 85437, updated on 6-Nov-2022

Summary

Official Symbol
ZCRB1provided by HGNC
Official Full Name
zinc finger CCHC-type and RNA binding motif containing 1provided by HGNC
Primary source
HGNC:HGNC:29620
See related
Ensembl:ENSG00000139168 MIM:610750; AllianceGenome:HGNC:29620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MADP1; RBM36; MADP-1; SNRNP31; ZCCHC19
Summary
Pre-mRNA splicing is catalyzed by the spliceosome. U12-type spliceosome binds U12-type pre-mRNAs and recognizes the 5' splice site and branch-point sequence. U11 and U12 snRNPs are components of U12-type spliceosome and function as a molecular bridge connecting both ends of the intron. The protein encoded by this gene contains a RNA recognition motif. It was identified as one of the protein components of U11/U12 snRNPs. This protein and many other U11/U12 snRNP proteins are highly conserved in organisms known to contain U12-type introns. These proteins have been shown to be essential for cell viability, suggesting the key roles in U12-type splicing. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 32.6), brain (RPKM 19.2) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ZCRB1 in Genome Data Viewer
Location:
12q12
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (42312086..42326094, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (42270020..42284029, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (42705888..42719896, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene insulin like growth factor 2 mRNA binding protein 2 pseudogene Neighboring gene uncharacterized LOC124902921 Neighboring gene microRNA 7851 Neighboring gene periphilin 1 Neighboring gene RNA, U6 small nuclear 249, pseudogene Neighboring gene FMR1 autosomal homolog 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC26805

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA splicing IC
Inferred by Curator
more info
PubMed 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of U12-type spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of U12-type spliceosomal complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
zinc finger CCHC-type and RNA-binding motif-containing protein 1
Names
U11/U12 small nuclear ribonucleoprotein 31 kDa protein
U11/U12 snRNP 31 kDa protein
U11/U12 snRNP 31K
U11/U12-31K
zinc finger CCHC-type and RNA binding motif 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033114.4NP_149105.3  zinc finger CCHC-type and RNA-binding motif-containing protein 1

    See identical proteins and their annotated locations for NP_149105.3

    Status: REVIEWED

    Source sequence(s)
    AB062361, BC022543, BI666919
    Consensus CDS
    CCDS8740.1
    UniProtKB/Swiss-Prot
    Q8TBF4, Q96TA6
    UniProtKB/TrEMBL
    A0A024R106
    Related
    ENSP00000266529.3, ENST00000266529.8
    Conserved Domains (2) summary
    cd12393
    Location:986
    RRM_ZCRB1; RNA recognition motif in Zinc finger CCHC-type and RNA-binding motif-containing protein 1 (ZCRB1) and similar proteins
    cl26705
    Location:97123
    AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    42312086..42326094 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020124.2XP_016875613.1  zinc finger CCHC-type and RNA-binding motif-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    G3V1V1
    Related
    ENSP00000504144.1, ENST00000676501.1
    Conserved Domains (2) summary
    PTZ00368
    Location:5682
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    cl17169
    Location:143
    RRM_SF; RNA recognition motif (RRM) superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    42270020..42284029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)