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MED4 Med4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854345, updated on 5-Jul-2025
Official Symbol
MED4
Official Full Name
Med4p
Primary source
SGD:S000005700
Locus tag
YOR174W
See related
AllianceGenome:SGD:S000005700; FungiDB:YOR174W; VEuPathDB:YOR174W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA polymerase II core promoter sequence-specific DNA binding activity. Involved in cellular response to heat and transcription by RNA polymerase II. Part of core mediator complex. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (658747..659601)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Yrm1p Neighboring gene 5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase Neighboring gene lysophospholipid acyltransferase Neighboring gene ferrochelatase HEM15

Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Evidence that Mediator is essential for Pol II transcription, but is not a required component of the preinitiation complex in vivo. Petrenko N, et al. Elife, 2017 Jul 12. PMID 28699889, Free PMC Article
  2. Mutual targeting of mediator and the TFIIH kinase Kin28. Guidi BW, et al. J Biol Chem, 2004 Jul 9. PMID 15126497
  3. Conserved structures of mediator and RNA polymerase II holoenzyme. Asturias FJ, et al. Science, 1999 Feb 12. PMID 9974391
  4. Mediator protein mutations that selectively abolish activated transcription. Myers LC, et al. Proc Natl Acad Sci U S A, 1999 Jan 5. PMID 9874773, Free PMC Article
  5. Hrs1/Med3 is a Cyc8-Tup1 corepressor target in the RNA polymerase II holoenzyme. Papamichos-Chronakis M, et al. J Biol Chem, 2000 Mar 24. PMID 10722672

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA polymerase II core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to heat IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of core mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of core mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Med4p
NP_014817.3
  • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    658747..659601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183593.3 → NP_014817.3  TPA: Med4p

    See identical proteins and their annotated locations for NP_014817.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2N0, Q12343
    UniProtKB/TrEMBL
    A0ABF7PIQ4, A6ZP17, B3LJK4, B5VS58, C7GN53, C8ZGT5, G2WN46, N1NVU0
    Conserved Domains (1) summary
    pfam10018
    Location:67 → 208
    Med4; Vitamin-D-receptor interacting Mediator subunit 4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12343.1

Gene LinkOut

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