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PUP1 proteasome core particle subunit beta 2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854328, updated on 18-Sep-2024

Summary

Official Symbol
PUP1
Official Full Name
proteasome core particle subunit beta 2
Primary source
SGD:S000005683
Locus tag
YOR157C
See related
AllianceGenome:SGD:S000005683; FungiDB:YOR157C; VEuPathDB:YOR157C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables endopeptidase activity. Involved in proteasomal ubiquitin-independent protein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in nucleus and proteasome storage granule. Part of proteasome core complex, beta-subunit complex. Orthologous to several human genes including PSMB7 (proteasome 20S subunit beta 7). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See PUP1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (630966..631751, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene IMP 5'-nucleotidase Neighboring gene SUMO ligase NFI1 Neighboring gene mitochondrial 37S ribosomal protein PET123 Neighboring gene mRNA splicing protein SME1

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables threonine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome core complex IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome core complex, beta-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of proteasome core complex, beta-subunit complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome core complex, beta-subunit complex IEA
Inferred from Electronic Annotation
more info
 
located_in proteasome storage granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
proteasome core particle subunit beta 2
NP_014800.3
  • Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    630966..631751 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183576.3NP_014800.3  TPA: proteasome core particle subunit beta 2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014800.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2L4, P25043
    UniProtKB/TrEMBL
    A6ZP01, B3LJI9, B5VS45, C7GN68, C8ZGR5, G2WN29, N1NYI3
    Conserved Domains (2) summary
    cd03763
    Location:30219
    proteasome_beta_type_7; proteasome beta type-7 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
    pfam12465
    Location:223257
    Pr_beta_C; Proteasome beta subunits C terminal