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IDH2 isocitrate dehydrogenase (NAD(+)) IDH2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854303, updated on 5-Aug-2018

Summary

Gene symbol
IDH2
Gene description
isocitrate dehydrogenase (NAD(+)) IDH2
Primary source
SGD:S000005662
Locus tag
YOR136W
Gene type
protein coding
RNA name
isocitrate dehydrogenase (NAD(+)) IDH2
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

Genomic context

See IDH2 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (580250..581359)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene elongation factor 2 Neighboring gene Bag7p Neighboring gene Sia1p Neighboring gene Rup1p

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
NAD binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to isocitrate dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
PubMed 
isocitrate dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
glutamate biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
isocitrate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
 
tricarboxylic acid cycle TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
mitochondrial isocitrate dehydrogenase complex (NAD+) IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
mitochondrion HDA PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
isocitrate dehydrogenase (NAD(+)) IDH2
NP_014779.1
  • Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase; complex catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    580250..581359
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183555.1NP_014779.1  TPA: isocitrate dehydrogenase (NAD(+)) IDH2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014779.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P28241
    Conserved Domains (1) summary
    TIGR00175
    Location:34369
    mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type
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