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LMO4 LIM domain only 4 [ Homo sapiens (human) ]

Gene ID: 8543, updated on 22-Sep-2022

Summary

Official Symbol
LMO4provided by HGNC
Official Full Name
LIM domain only 4provided by HGNC
Primary source
HGNC:HGNC:6644
See related
Ensembl:ENSG00000143013 MIM:603129; AllianceGenome:HGNC:6644
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a cysteine-rich protein that contains two LIM domains but lacks a DNA-binding homeodomain. The encoded protein may play a role as a transcriptional regulator or as an oncogene. [provided by RefSeq, Aug 2008]
Expression
Ubiquitous expression in brain (RPKM 22.8), stomach (RPKM 12.3) and 24 other tissues See more
Orthologs
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Genomic context

See LMO4 in Genome Data Viewer
Location:
1p22.3
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (87328880..87348923)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (87171579..87191625)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (87794563..87814606)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2801 Neighboring gene Sharpr-MPRA regulatory region 9281 Neighboring gene VISTA enhancer hs809 Neighboring gene VISTA enhancers hs174 and hs322 Neighboring gene long intergenic non-protein coding RNA 1364 Neighboring gene uncharacterized LOC105378833

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis.
EBI GWAS Catalog
Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in motor neuron axon guidance IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in neural tube closure ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell activation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell fate specification IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in spinal cord association neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in spinal cord motor neuron cell fate specification IEA
Inferred from Electronic Annotation
more info
 
involved_in thymus development IEA
Inferred from Electronic Annotation
more info
 
involved_in ventral spinal cord interneuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in ventricular septum development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 
located_in cell leading edge ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transcription regulator complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
LIM domain transcription factor LMO4
Names
LIM domain only protein 4
LIM-only 4 protein
LMO-4
breast tumor autoantigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369491.1NP_001356420.1  LIM domain transcription factor LMO4

    Status: REVIEWED

    Source sequence(s)
    AC092392
    UniProtKB/Swiss-Prot
    O88894
    Related
    ENSP00000359573.1, ENST00000370542.1
    Conserved Domains (2) summary
    cd09386
    Location:2377
    LIM1_LMO4; The first LIM domain of LMO4 (LIM domain only protein 4)
    cd09387
    Location:87141
    LIM2_LMO4; The second LIM domain of LMO4 (LIM domain only protein 4)
  2. NM_006769.4NP_006760.1  LIM domain transcription factor LMO4

    See identical proteins and their annotated locations for NP_006760.1

    Status: REVIEWED

    Source sequence(s)
    AC092392, AI962216, BU580860, BU619915, U24576
    Consensus CDS
    CCDS713.1
    UniProtKB/Swiss-Prot
    O88894, P61968
    Related
    ENSP00000359575.4, ENST00000370544.10
    Conserved Domains (2) summary
    cd09386
    Location:2377
    LIM1_LMO4; The first LIM domain of LMO4 (LIM domain only protein 4)
    cd09387
    Location:87141
    LIM2_LMO4; The second LIM domain of LMO4 (LIM domain only protein 4)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    87328880..87348923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432941.1XP_047288897.1  LIM domain transcription factor LMO4 isoform X1

    UniProtKB/Swiss-Prot
    O88894

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    87171579..87191625
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)