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UBP2 ubiquitin-specific protease UBP2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854291, updated on 2-Nov-2024

Summary

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Official Symbol
UBP2
Official Full Name
ubiquitin-specific protease UBP2
Primary source
SGD:S000005650
Locus tag
YOR124C
See related
AllianceGenome:SGD:S000005650; FungiDB:YOR124C; VEuPathDB:YOR124C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables cysteine-type deubiquitinase activity. Involved in several processes, including cellular response to hydrogen peroxide; positive regulation of mitochondrial fusion; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human USP25 (ubiquitin specific peptidase 25) and USP28 (ubiquitin specific peptidase 28). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See UBP2 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (554824..558642, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene profilin Neighboring gene Leo1p Neighboring gene putative monooxygenase CAT5 Neighboring gene isoamyl acetate-hydrolyzing esterase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein expression using cotranslational fusion and cleavage of ubiquitin. Mutagenesis of the glutathione-binding site of human Pi class glutathione S-transferase. Baker RT, et al. J Biol Chem, 1994 Oct 14. PMID 7929235
  2. Glucose activation of the yeast plasma membrane H+-ATPase requires the ubiquitin-proteasome proteolytic pathway. de la Fuente N, et al. FEBS Lett, 1997 Jul 14. PMID 9271226
  3. A dual role for K63-linked ubiquitin chains in multivesicular body biogenesis and cargo sorting. Erpapazoglou Z, et al. Mol Biol Cell, 2012 Jun. PMID 22493318, Free PMC Article
  4. The deubiquitinating enzyme Ubp2 modulates Rsp5-dependent Lys63-linked polyubiquitin conjugates in Saccharomyces cerevisiae. Kee Y, et al. J Biol Chem, 2006 Dec 1. PMID 17028178
  5. Two deubiquitylases act on mitofusin and regulate mitochondrial fusion along independent pathways. Anton F, et al. Mol Cell, 2013 Feb 7. PMID 23317502

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mdm30-Ubp2-Rsp5 crosstalk regulates mitochondrial fusion by coordinating an intricate balance between Fzo1 turnover and the status of fatty acids saturation.
    Title: An ubiquitin-dependent balance between mitofusin turnover and fatty acids desaturation regulates mitochondrial fusion.
  2. Ubp2 and Ubp3 deubiquitinases are required for the proteasomal degradation of cytosolic misfolded proteins targeted by Rsp5 after heat-shock
    Title: Deubiquitinase activity is required for the proteasomal degradation of misfolded cytosolic proteins upon heat-stress.
  3. Results uncover a novel function for DUBs in the endocytic pathway by which Ubp2 and Ubp15 positively regulate the ART-Rsp5 network.
    Title: Deubiquitinating enzymes Ubp2 and Ubp15 regulate endocytosis by limiting ubiquitination and degradation of ARTs.
  4. Ubp2 has a role as a positive regulator of Rsp5-mediated membrane protein trafficking subsequent to endocytosis
    Title: Interaction of the deubiquitinating enzyme Ubp2 and the e3 ligase Rsp5 is required for transporter/receptor sorting in the multivesicular body pathway.
  5. Ubp2 modulates Lys(63)-polyubiquitination of Rsp5 substrates in vivo, including ubiquitination of two newly identified Rsp5 substrates, Csr2 and Ecm21
    Title: The deubiquitinating enzyme Ubp2 modulates Rsp5-dependent Lys63-linked polyubiquitin conjugates in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type deubiquitinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitochondrial fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein deubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IC
Inferred by Curator
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin-specific protease UBP2
NP_014767.3
  • Ubiquitin-specific protease; removes ubiquitin from ubiquitinated proteins; controls K63 homeostasis during oxidative stress; deubiquitinates Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    554824..558642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183543.3 → NP_014767.3  TPA: ubiquitin-specific protease UBP2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014767.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2I2, Q01476, Q99357
    UniProtKB/TrEMBL
    A6ZNX1, N1P355
    Conserved Domains (2) summary
    cd02666
    Location:735 → 1256
    Peptidase_C19J; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam13446
    Location:585 → 641
    RPT; A repeated domain in UCH-protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01476.2

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