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RGS2 GTPase-activating protein RGS2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854274, updated on 24-Jan-2026
Official Symbol
RGS2
Official Full Name
GTPase-activating protein RGS2
Primary source
SGD:S000005633
Locus tag
YOR107W
See related
AllianceGenome:SGD:S000005633; FungiDB:YOR107W; VEuPathDB:YOR107W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTPase activator activity. Involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma and essential hypertension. Orthologous to several human genes including RGS5 (regulator of G protein signaling 5). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (521353..522282)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Pin2p Neighboring gene uncharacterized protein Neighboring gene SNAP receptor VAM3 Neighboring gene 2-isopropylmalate synthase LEU9 Neighboring gene phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP53

Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Galpha protein dependent and independent effects of human RGS1 expression in yeast. Li XY, et al. Cell Signal, 2004 Jan. PMID 14607274
  2. Mechanisms governing subcellular localization and function of human RGS2. Heximer SP, et al. J Biol Chem, 2001 Apr 27. PMID 11278586
  3. A novel regulator of G protein signalling in yeast, Rgs2, downregulates glucose-activation of the cAMP pathway through direct inhibition of Gpa2. Versele M, et al. EMBO J, 1999 Oct 15. PMID 10523302, Free PMC Article
  4. Regulation of longevity by regulator of G-protein signaling protein, Loco. Lin YR, et al. Aging Cell, 2011 Jun. PMID 21255223
  5. QTL mapping of volatile compound production in Saccharomyces cerevisiae during alcoholic fermentation. Eder M, et al. BMC Genomics, 2018 Mar 1. PMID 29490607, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
GTPase-activating protein RGS2
NP_014750.3
  • Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    521353..522282
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183526.3 → NP_014750.3  GTPase-activating protein RGS2

    See identical proteins and their annotated locations for NP_014750.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2G6, Q99188
    UniProtKB/TrEMBL
    G2WMY2, N1NYE3
    Conserved Domains (1) summary
    cd07440
    Location:42 → 154
    RGS; Regulator of G protein signaling (RGS) domain superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99188.1

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