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TMA46 translation machinery-associated protein TMA46 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854258, updated on 6-Jul-2025
Official Symbol
TMA46
Official Full Name
translation machinery-associated protein TMA46
Primary source
SGD:S000005617
Locus tag
YOR091W
See related
AllianceGenome:SGD:S000005617; FungiDB:YOR091W; VEuPathDB:YOR091W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables mRNA binding activity. Involved in cytoplasmic translation. Located in cytoplasm. Orthologous to human ZC3H15 (zinc finger CCCH-type containing 15). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See TMA46 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (493433..494470)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Rab family GTPase VPS21 Neighboring gene type 2C protein phosphatase PTC5 Neighboring gene putative ATPase ECM3 Neighboring gene Cmr2p

Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Rbg1-Tma46 dimer structure reveals new functional domains and their role in polysome recruitment. Francis SM, et al. Nucleic Acids Res, 2012 Nov. PMID 23002146, Free PMC Article
  2. Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells. Zeng F, et al. Cell Rep, 2021 Oct 26. PMID 34706231, Free PMC Article
  3. Cell growth control by stable Rbg2/Gir2 complex formation under amino acid starvation. Ishikawa K, et al. Genes Cells, 2013 Oct. PMID 23899355
  4. Saccharomyces cerevisiae Rbg1 protein and its binding partner Gir2 interact on Polyribosomes with Gcn1. Wout PK, et al. Eukaryot Cell, 2009 Jul. PMID 19448108, Free PMC Article
  5. The highly conserved eukaryotic DRG factors are required for efficient translation in a manner redundant with the putative RNA helicase Slh1. Daugeron MC, et al. Nucleic Acids Res, 2011 Mar. PMID 21076151, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells.
    Title: Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables mRNA binding HDA PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
translation machinery-associated protein TMA46
NP_014734.2
  • hypothetical protein that associates with translating ribosomes; interacts with GTPase Rbg1p

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    493433..494470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183510.1 → NP_014734.2  TPA: translation machinery-associated protein TMA46

    See identical proteins and their annotated locations for NP_014734.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2F2, Q12000
    UniProtKB/TrEMBL
    A0ABF7PIQ0, B3LJD7, B5VRY7, C7GMP3, C8ZI52, G2WMW8, N1NYD0
    Conserved Domains (1) summary
    COG5252
    Location:1 → 336
    COG5252; Uncharacterized conserved protein, contains CCCH-type Zn-finger protein [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12000.2

Gene LinkOut

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