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LPX1 triglyceride lipase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854251, updated on 14-Nov-2024

Summary

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Official Symbol
LPX1
Official Full Name
triglyceride lipase
Primary source
SGD:S000005610
Locus tag
YOR084W
See related
AllianceGenome:SGD:S000005610; FungiDB:YOR084W; VEuPathDB:YOR084W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables triacylglycerol lipase activity. Involved in triglyceride catabolic process. Located in peroxisomal matrix. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See LPX1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (480587..481750)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene triacylglycerol lipase Neighboring gene transcriptional repressor WHI5 Neighboring gene dolichyl-diphosphooligosaccharide--protein glycotransferase OST3 Neighboring gene tricalbin

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lpx1p is a peroxisomal lipase required for normal peroxisome morphology. Thoms S, et al. FEBS J, 2008 Feb. PMID 18199283
  2. The unusual extended C-terminal helix of the peroxisomal α/β-hydrolase Lpx1 is involved in dimer contacts but dispensable for dimerization. Thoms S, et al. J Struct Biol, 2011 Sep. PMID 21741480
  3. Screening for hydrolytic enzymes reveals Ayr1p as a novel triacylglycerol lipase in Saccharomyces cerevisiae. Ploier B, et al. J Biol Chem, 2013 Dec 13. PMID 24187129, Free PMC Article
  4. The putative Saccharomyces cerevisiae hydrolase Ldh1p is localized to lipid droplets. Thoms S, et al. Eukaryot Cell, 2011 Jun. PMID 21478430, Free PMC Article
  5. Transcriptome profiling to identify genes involved in peroxisome assembly and function. Smith JJ, et al. J Cell Biol, 2002 Jul 22. PMID 12135984, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables triacylglycerol lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables triacylglycerol lipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in triglyceride catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in triglyceride catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in peroxisomal matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisomal matrix IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
triglyceride lipase
NP_014727.1
  • Peroxisomal matrix-localized lipase; required for normal peroxisome morphology; contains a peroxisomal targeting signal type 1 (PTS1) and a lipase motif; peroxisomal import requires the PTS1 receptor, Pex5p and self-interaction; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; oleic acid inducible

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    480587..481750
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183503.1 → NP_014727.1  TPA: triglyceride lipase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014727.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2E6, Q12405
    UniProtKB/TrEMBL
    A6ZNT5, B3LJD2, C7GT32, C8ZI46, G2WMW1, N1P322
    Conserved Domains (1) summary
    COG0596
    Location:55 → 337
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12405.1

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