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DIA2 DNA-binding SCF ubiquitin ligase subunit DIA2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854247, updated on 5-Sep-2021

Summary

Gene symbol
DIA2
Gene description
DNA-binding SCF ubiquitin ligase subunit DIA2
Primary source
SGD:S000005606
Locus tag
YOR080W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YOR29-31
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Genomic context

See DIA2 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (474594..476792)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Bud21p Neighboring gene Mn(2+) transporter ATX2 Neighboring gene triacylglycerol lipase Neighboring gene transcriptional repressor WHI5

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables DNA replication origin binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with nuclear replication fork IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DNA-binding SCF ubiquitin ligase subunit DIA2
NP_014723.2
  • Origin-binding F-box protein; forms SCF ubiquitin ligase complex with Skp1p and Cdc53p; functions in ubiquitination of silent chromatin structural protein Sir4p; required to target Cdc6p for destruction during G1 phase; required for deactivation of Rad53 checkpoint kinase, completion of DNA replication during recovery from DNA damage, assembly of RSC complex, RSC-mediated transcription regulation, and nucleosome positioning; involved in invasive and pseudohyphal growth

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    474594..476792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183499.1NP_014723.2  TPA: DNA-binding SCF ubiquitin ligase subunit DIA2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014723.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q08496
    Conserved Domains (4) summary
    sd00033
    Location:483511
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:553581
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00006
    Location:1943
    TPR; TPR repeat [structural motif]
    pfam00646
    Location:209241
    F-box; F-box domain
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