CDC21 thymidylate synthase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: CDC21
Official Full Name: thymidylate synthase
Primary source: SGD:S000005600
Locus tag: YOR074C
See related: AllianceGenome:SGD:S000005600; FungiDB:YOR074C; VEuPathDB:YOR074C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CRT9; TMP1
Summary: Enables thymidylate synthase activity. Involved in dTMP biosynthetic process. Located in nuclear periphery. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; digenic dyskeratosis congenita; gastrointestinal system cancer (multiple); hematologic cancer (multiple); and rheumatoid arthritis. Orthologous to human TYMS (thymidylate synthetase). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

28-bp tandem repeat 3R allele and 6-bp deletion allele (rs34489327) may favor non-response to methotrexate in south Indian Tamils
Title: Effect of thymidylate synthase (TYMS) gene polymorphisms with methotrexate treatment outcome in south Indian Tamil patients with rheumatoid arthritis.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables thymidylate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thymidylate synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables thymidylate synthase activity	IEA Inferred from Electronic Annotation more info
enables thymidylate synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity, transferring one-carbon groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in dTMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dTMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in dTMP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dTTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_014717.2

Thymidylate synthase; required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S; human homolog TYMSOS can complement yeast cdc21 temperature-sensitive mutant at restrictive temperature