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ALG8 dolichyl-P-Glc:Glc1Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854233, updated on 3-Jun-2026
Official Symbol
ALG8
Official Full Name
dolichyl-P-Glc:Glc1Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase
Primary source
SGD:S000005593
Locus tag
YOR067C
See related
AllianceGenome:SGD:S000005593; FungiDB:YOR067C; VEuPathDB:YOR067C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YOR29-18
Summary
Enables dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity. Involved in dolichol-linked oligosaccharide biosynthetic process. Located in endoplasmic reticulum membrane. Used to study congenital disorder of glycosylation type I. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ih and polycystic liver disease 3. Orthologous to human ALG8 (ALG8 alpha-1,3-glucosyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (451729..453462, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene ubiquinol--cytochrome-c reductase catalytic subunit CYT1 Neighboring gene Msa1p Neighboring gene Vam10p Neighboring gene sorting nexin 1 Neighboring gene GTPase-activating protein GYP1

Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Glycosylation of yeast exoglucanase sequons in alg mutants deficient in the glucosylation steps of the lipid-linked oligosaccharide. Presence of glucotriose unit in Dol-PP-GlcNAc2Man9Glc3 influences both glycosylation efficiency and selection of N-linked sites. Muñoz MD, et al. Biochim Biophys Acta, 1994 Dec 15. PMID 7803465
  2. A new yeast mutation in the glucosylation steps of the asparagine-linked glycosylation pathway. Formation of a novel asparagine-linked oligosaccharide containing two glucose residues. Runge KW, et al. J Biol Chem, 1986 Nov 25. PMID 3536907
  3. Clinical and molecular features of three patients with congenital disorders of glycosylation type Ih (CDG-Ih) (ALG8 deficiency). Schollen E, et al. J Med Genet, 2004 Jul. PMID 15235028, Free PMC Article
  4. New phenotype of mutations deficient in glucosylation of the lipid-linked oligosaccharide: cloning of the ALG8 locus. Stagljar I, et al. Proc Natl Acad Sci U S A, 1994 Jun 21. PMID 8016100, Free PMC Article
  5. Effects of N-glycosylation and inositol on the ER stress response in yeast Saccharomyces cerevisiae. Uchimura S, et al. Biosci Biotechnol Biochem, 2005 Jul. PMID 16041130

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity RCA
inferred from Reviewed Computational Analysis
more info
  
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dolichol-linked oligosaccharide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dolichol-linked oligosaccharide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dolichol-linked oligosaccharide biosynthetic process RCA
inferred from Reviewed Computational Analysis
more info
  
involved_in protein N-linked glycosylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein N-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
  
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Preferred Names
dolichyl-P-Glc:Glc1Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase
NP_014710.1
  • Glucosyl transferase; involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p; human homolog ALG8 can complement yeast null mutant

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    451729..453462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183486.1 → NP_014710.1  dolichyl-P-Glc:Glc1Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase

    See identical proteins and their annotated locations for NP_014710.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2D0, P40351
    UniProtKB/TrEMBL
    A6ZNR9, B3LJB6, C7GX51, C8ZI28, G2WMU5, N1P310
    Conserved Domains (1) summary
    pfam03155
    Location:52 → 562
    Alg6_Alg8; ALG6, ALG8 glycosyltransferase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40351.1

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