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ASE1 Ase1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854223, updated on 9-Dec-2024

Summary

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Official Symbol
ASE1
Official Full Name
Ase1p
Primary source
SGD:S000005584
Locus tag
YOR058C
See related
AllianceGenome:SGD:S000005584; FungiDB:YOR058C; VEuPathDB:YOR058C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YOR29-09
Summary
Enables microtubule binding activity. Involved in microtubule cytoskeleton organization and septum digestion after cytokinesis. Located in mitotic spindle midzone and nuclear microtubule. Orthologous to human PRC1 (protein regulator of cytokinesis 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ASE1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (433688..436345, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene rRNA-binding endoribonuclease Neighboring gene co-chaperone SGT1 Neighboring gene tRNA-Lys Neighboring gene putative hydrolase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. APC-mediated proteolysis of Ase1 and the morphogenesis of the mitotic spindle. Juang YL, et al. Science, 1997 Feb 28. PMID 9036857
  2. The molecular function of Ase1p: evidence for a MAP-dependent midzone-specific spindle matrix. Microtubule-associated proteins. Schuyler SC, et al. J Cell Biol, 2003 Feb 17. PMID 12591913, Free PMC Article
  3. Two microtubule-associated proteins required for anaphase spindle movement in Saccharomyces cerevisiae. Pellman D, et al. J Cell Biol, 1995 Sep. PMID 7559759, Free PMC Article
  4. Phosphorylation-dependent protein interactions at the spindle midzone mediate cell cycle regulation of spindle elongation. Khmelinskii A, et al. Dev Cell, 2009 Aug. PMID 19686685
  5. Replicative stress induces intragenic transcription of the ASE1 gene that negatively regulates Ase1 activity. McKnight K, et al. Curr Biol, 2014 May 19. PMID 24768052, Free PMC Article

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Slk19 enhances cross-linking of microtubules by Ase1 and Stu1.
    Title: Slk19 enhances cross-linking of microtubules by Ase1 and Stu1.
  2. Ase1 domains dynamically slow anaphase spindle elongation and recruit Bim1 to the midzone.
    Title: Ase1 domains dynamically slow anaphase spindle elongation and recruit Bim1 to the midzone.
  3. When yeast cells were treated with hydroxyurea to block DNA synthesis and induce replication stress, we found that Ase1, a conserved spindle midzone protein, appeared as two short protein isoforms in addition to the full-length protein.
    Title: Replicative stress induces intragenic transcription of the ASE1 gene that negatively regulates Ase1 activity.
  4. the requirement of CDK for phosphorylation of the spindle midzone component Ase1p and its significance to spindle assembly
    Title: Ase1p phosphorylation by cyclin-dependent kinase promotes correct spindle assembly in S. cerevisiae.
  5. Review identifies Ase1 as a key Cdc14 substrate and elucidates the coordination of spindle midzone assembly with metaphase to anaphase transition.
    Title: Assembling the spindle midzone in the right place at the right time.
  6. Ase1p and Cin8p affect nuclear positioning through astral micro-tubule-dependent mechanisms.
    Title: The spindle midzone microtubule-associated proteins Ase1p and Cin8p affect the number and orientation of astral microtubules in Saccharomyces cerevisiae.
  7. A pathway regulating IPL1 and the spindle midzone protein Ase1 regulates spindle assembly.
    Title: A pathway containing the Ipl1/aurora protein kinase and the spindle midzone protein Ase1 regulates yeast spindle assembly.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in initial mitotic spindle pole body separation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in microtubule bundle formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic spindle elongation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic spindle elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle midzone assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in septum digestion after cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spindle midzone assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule HDA PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle midzone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ase1p
NP_116582.1
  • Mitotic spindle midzone-localized microtubule bundling protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    433688..436345 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183477.1 → NP_116582.1  TPA: Ase1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116582.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2C1, P50275
    UniProtKB/TrEMBL
    A6ZNR0, C8ZI19, G2WMT6, N1P305
    Conserved Domains (1) summary
    pfam03999
    Location:121 → 800
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50275.1

Gene LinkOut

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