SGT1 co-chaperone SGT1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SGT1
Official Full Name: co-chaperone SGT1
Primary source: SGD:S000005583
Locus tag: YOR057W
See related: AllianceGenome:SGD:S000005583; FungiDB:YOR057W; VEuPathDB:YOR057W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables chaperone binding activity and protein-macromolecule adaptor activity. Involved in kinetochore assembly. Part of ubiquitin ligase complex. Orthologous to human SUGT1 (SGT1 homolog, MIS12 kinetochore complex assembly cochaperone). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SGT1 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (432186..433373)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Report the importance of Hsp90/Sgt1 system in controlling cell plasticity.
Title: The Plasticity of the Hsp90 Co-chaperone System.
overexpression of other co-chaperones further disrupts the essential functions of Cns1 and Sgt1. However, the specificity of the negative effects indicates that only a subset of co-chaperones competes with Sgt1 or Cns1 for binding to Hsp90.
Title: Mutation of essential Hsp90 co-chaperones SGT1 or CNS1 renders yeast hypersensitive to overexpression of other co-chaperones.
protein kinase CK2 phosphorylates Ser(361) on Sgt1, and this phosphorylation inhibits Sgt1 dimerization
Title: Sgt1 dimerization is negatively regulated by protein kinase CK2-mediated phosphorylation at Ser361.
Sgt1 dimerization is required for kinetochore assembly.
Title: Sgt1 dimerization is required for yeast kinetochore assembly.
Data show that the amino terminus of Sgt1p interacts with CBF3 subunits Skp1p and Ctf13p.
Title: The interaction between Sgt1p and Skp1p is regulated by HSP90 chaperones and is required for proper CBF3 assembly.
Sgt1p acts as a "client adaptor" recruiting specific clients to Hsp82p co-chaperone complexes
Title: Sgt1p is a unique co-chaperone that acts as a client adaptor to link Hsp90 to Skp1p.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables protein-folding chaperone binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-folding chaperone binding	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in kinetochore assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in protein quality control for misfolded or incompletely synthesized proteins	IDA Inferred from Direct Assay more info	PubMed
involved_in protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
part_of ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: co-chaperone SGT1

NP_014700.1

Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

432186..433373

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183476.1 → NP_014700.1 TPA: co-chaperone SGT1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014700.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2C0, E9P8U7, Q08446

UniProtKB/TrEMBL

C7GSN0, G2WMT5, N1NVR5

Conserved Domains (2) summary

COG5091
Location:10 → 395

SGT1; Suppressor of G2 allele of skp1 and related proteins [General function prediction only]

sd00006
Location:37 → 77

TPR; TPR repeat [structural motif]