U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RSB1 phospholipid-translocating ATPase RSB1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854214, updated on 7-Jun-2026
Official Symbol
RSB1
Official Full Name
phospholipid-translocating ATPase RSB1
Primary source
SGD:S000005575
Locus tag
YOR049C
See related
AllianceGenome:SGD:S000005575; FungiDB:YOR049C; VEuPathDB:YOR049C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables long-chain fatty acid transmembrane transporter activity. Involved in phospholipid translocation and sphingoid long-chain base transport. Located in endoplasmic reticulum and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See RSB1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (422668..423732, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Std1p Neighboring gene ssRNA exonuclease RAT1 Neighboring gene Ett1p Neighboring gene Tmc1p

Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Identification and characterization of a Saccharomyces cerevisiae gene, RSB1, involved in sphingoid long-chain base release. Kihara A, et al. J Biol Chem, 2002 Aug 16. PMID 12034738
  2. Long chain base tolerance in Saccharomyces cerevisiae is induced by retrograde signals from the mitochondria. Panwar SL, et al. J Biol Chem, 2006 Mar 10. PMID 16407254
  3. Loop 5 region is important for the activity of the long-chain base transporter Rsb1. Makuta H, et al. J Biochem, 2017 Feb 1. PMID 28175317
  4. Long-chain bases of sphingolipids are transported into cells via the acyl-CoA synthetases. Narita T, et al. Sci Rep, 2016 May 3. PMID 27136724, Free PMC Article
  5. Transcriptional response to deletion of the phosphatidylserine decarboxylase Psd1p in the yeast Saccharomyces cerevisiae. Gsell M, et al. PLoS One, 2013. PMID 24146988, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that tryptophan transport is increased in pdr5Delta/yor1 strains and reduced in rsb1Delta cells, and the localization and vacuolar degradation of Tat2 were affected in these genetic backgrounds.
    Title: Regulation of yeast nutrient permease endocytosis by ATP-binding cassette transporters and a seven-transmembrane protein, RSB1.
  2. The pH-responsive Rim101 pathway, the protein kinase Mck1, and the transcription factor Mot3 all act in lipid asymmetry signaling and the Rim101 pathway was activated in response to a change in lipid asymmetry.
    Title: The Rim101 pathway is involved in Rsb1 expression induced by altered lipid asymmetry.
  3. Activation of RSB1 transcription is an important feature of the retrograde response allowing normal detoxification of an endogenous sphingolipid precursor.
    Title: Long chain base tolerance in Saccharomyces cerevisiae is induced by retrograde signals from the mitochondria.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables long-chain fatty acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in long-chain fatty acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid translocation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sphingoid long-chain base transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sphingoid long-chain base transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fungal-type vacuole HDA PubMed 
is_active_in fungal-type vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
phospholipid-translocating ATPase RSB1
NP_014692.1
  • Sphingoid long-chain base (LCB) efflux transporter; integral membrane transporter that localizes to the plasma membrane and may transport long chain bases (LCBs) from the cytoplasmic side toward the extracytoplasmic side of the membrane; role in glycerophospholipid translocation; suppressor of the sphingoid LCB sensitivity of an LCB-lyase mutation

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    422668..423732 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183468.1 → NP_014692.1  phospholipid-translocating ATPase RSB1

    See identical proteins and their annotated locations for NP_014692.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2B5, Q08417
    UniProtKB/TrEMBL
    G2WMT0, N1NY97
    Conserved Domains (1) summary
    pfam04479
    Location:37 → 283
    RTA1; RTA1 like protein
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools