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HIR2 Hir2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854203, updated on 15-Mar-2026
Official Symbol
HIR2
Official Full Name
Hir2p
Primary source
SGD:S000005564
Locus tag
YOR038C
See related
AllianceGenome:SGD:S000005564; FungiDB:YOR038C; VEuPathDB:YOR038C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SPT1
Summary
Enables transcription corepressor activity. Contributes to DNA binding activity and nucleosome binding activity. Involved in negative regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase III; and transcription elongation-coupled chromatin remodeling. Located in cytosol and nucleus. Part of HIR complex. Orthologous to human HIRA (histone cell cycle regulator). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See HIR2 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (402761..405388, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene SNAP receptor PEP12 Neighboring gene oxidoreductase Neighboring gene casein kinase 2 regulatory subunit CKB2 Neighboring gene hydroxyacylglutathione hydrolase GLO4

Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structural insights into the interaction of Hir2 and Hpc2 in the yeast Hir histone chaperone complex. Tseng CH, et al. Structure, 2025 Aug 7. PMID 40449483
  2. Functional analysis of histones H2A and H2B in transcriptional repression in Saccharomyces cerevisiae. Recht J, et al. Mol Cell Biol, 1996 Jun. PMID 8649361, Free PMC Article
  3. Subnuclear localization and mitotic phosphorylation of HIRA, the human homologue of Saccharomyces cerevisiae transcriptional regulators Hir1p/Hir2p. De Lucia F, et al. Biochem J, 2001 Sep 1. PMID 11513744, Free PMC Article
  4. A human homolog of the S. cerevisiae HIR1 and HIR2 transcriptional repressors cloned from the DiGeorge syndrome critical region. Lamour V, et al. Hum Mol Genet, 1995 May. PMID 7633437
  5. Characterization of HIR1 and HIR2, two genes required for regulation of histone gene transcription in Saccharomyces cerevisiae. Sherwood PW, et al. Mol Cell Biol, 1993 Jan. PMID 8417331, Free PMC Article

See all (96) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to nucleosome binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase III IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase III IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleosome assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of chromatin organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription elongation-coupled chromatin remodeling IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of HIR complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of HIR complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of HIR complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Hir2p
NP_014681.1
  • Subunit of HIR nucleosome assembly complex; involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p; relocalizes to the cytosol in response to hypoxia

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    402761..405388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183457.1 → NP_014681.1  Hir2p

    See identical proteins and their annotated locations for NP_014681.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2A5, P32480
    UniProtKB/TrEMBL
    B3LJ91
    Conserved Domains (3) summary
    sd00039
    Location:123 → 163
    7WD40; WD40 repeat [structural motif]
    pfam07569
    Location:581 → 816
    Hira; TUP1-like enhancer of split
    cl29593
    Location:172 → 350
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32480.2

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