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SHE4 She4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854200, updated on 6-Jul-2026
Official Symbol
SHE4
Official Full Name
She4p
Primary source
SGD:S000005561
Locus tag
YOR035C
See related
AllianceGenome:SGD:S000005561; FungiDB:YOR035C; VEuPathDB:YOR035C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DIM1
Summary
Enables myosin binding activity. Involved in intracellular mRNA localization and mating type switching. Located in cytoplasm. Human ortholog(s) of this gene implicated in cataract 43 and myofibrillar myopathy 11. Orthologous to several human genes including UNC45B (unc-45 myosin chaperone B). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See SHE4 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (397735..400104, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene putative palmitoyltransferase AKR2 Neighboring gene uncharacterized protein Neighboring gene SNAP receptor PEP12 Neighboring gene oxidoreductase

Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. UCS protein function is partially restored in the Saccharomyces cerevisiae she4 mutant with expression of the human UNC45-GC, but not UNC45-SM. Escalante SG, et al. Cell Stress Chaperones, 2018 Jul. PMID 29288355, Free PMC Article
  2. UNC-45/CRO1/She4p (UCS) protein forms elongated dimer and joins two myosin heads near their actin binding region. Shi H, et al. Proc Natl Acad Sci U S A, 2010 Dec 14. PMID 21115842, Free PMC Article
  3. Localization of ASH1 mRNA particles in living yeast. Bertrand E, et al. Mol Cell, 1998 Oct. PMID 9809065
  4. Yeast UCS proteins promote actomyosin interactions and limit myosin turnover in cells. Lord M, et al. Proc Natl Acad Sci U S A, 2008 Jun 10. PMID 18523008, Free PMC Article
  5. The myosin motor, Myo4p, binds Ash1 mRNA via the adapter protein, She3p. Takizawa PA, et al. Proc Natl Acad Sci U S A, 2000 May 9. PMID 10792032, Free PMC Article

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that a UCS dimer in She4 links two myosins at their motor domains and thereby functions as one of the determinants for step size of myosin on actin filaments.
    Title: UNC-45/CRO1/She4p (UCS) protein forms elongated dimer and joins two myosin heads near their actin binding region.
  2. UCS proteins promote myosin stability and interactions with actin.
    Title: Yeast UCS proteins promote actomyosin interactions and limit myosin turnover in cells.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables Hsp90 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables myosin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in intracellular mRNA localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mating type switching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
She4p
NP_014678.1
  • Protein containing a UCS (UNC-45/CRO1/SHE4) domain; binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    397735..400104 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183454.1 → NP_014678.1  She4p

    See identical proteins and their annotated locations for NP_014678.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2A2, P51534
    UniProtKB/TrEMBL
    B3LJ88
    Conserved Domains (1) summary
    pfam11701
    Location:167 → 316
    UNC45-central; Myosin-binding striated muscle assembly central
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51534.2

Gene LinkOut

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