DDL1 putative carboxylic ester hydrolase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: DDL1
Official Full Name: putative carboxylic ester hydrolase
Primary source: SGD:S000005548
Locus tag: YOR022C
See related: AllianceGenome:SGD:S000005548; FungiDB:YOR022C; VEuPathDB:YOR022C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables phospholipase activity. Involved in cardiolipin metabolic process and phosphatidylethanolamine metabolic process. Located in mitochondrial matrix. Used to study hereditary spastic paraplegia 28 and hereditary spastic paraplegia 54. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 28 and hereditary spastic paraplegia 54. Orthologous to human DDHD1 (DDHD domain containing 1); DDHD2 (DDHD domain containing 2); and SEC23IP (SEC23 interacting protein). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables glycerophospholipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerophospholipase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycerophospholipase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glycerophospholipase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables glycerophospholipid phospholipase A1 activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cardiolipin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylethanolamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_014665.1

DDHD domain-containing phospholipase A1; mitochondrial matrix enzyme with sn-1-specific activity, hydrolyzing cardiolipin, PE, PC, PG and PA; implicated in remodeling of mitochondrial phospholipids; antagonistically regulated by Aft1p and Aft2p; in humans, mutations in DDHD1 and DDHD2 genes cause specific types of hereditary spastic paraplegia, while DDL1-defective yeast share similar phenotypes such as mitochondrial dysfunction and defects in lipid metabolism