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SFM1 protein-arginine N-methyltransferase SFM1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854186, updated on 10-Feb-2026
Official Symbol
SFM1
Official Full Name
protein-arginine N-methyltransferase SFM1
Primary source
SGD:S000005547
Locus tag
YOR021C
See related
AllianceGenome:SGD:S000005547; FungiDB:YOR021C; VEuPathDB:YOR021C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein-arginine omega-N monomethyltransferase activity. Involved in peptidyl-arginine methylation. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See SFM1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (372798..373439, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Hsp10p Neighboring gene Mco10p Neighboring gene putative carboxylic ester hydrolase Neighboring gene Ahc1p

Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Probabilistic protein function prediction from heterogeneous genome-wide data. Nariai N, et al. PLoS One, 2007 Mar 28. PMID 17396164, Free PMC Article
  2. Structural basis for Sfm1 functioning as a protein arginine methyltransferase. Lv F, et al. Cell Discov, 2015. PMID 27462434, Free PMC Article
  3. Identification of methylated proteins in the yeast small ribosomal subunit: a role for SPOUT methyltransferases in protein arginine methylation. Young BD, et al. Biochemistry, 2012 Jun 26. PMID 22650761, Free PMC Article
  4. Ribosomal protein methyltransferases in the yeast Saccharomyces cerevisiae: Roles in ribosome biogenesis and translation. Al-Hadid Q, et al. Biochem Biophys Res Commun, 2016 Feb 12. PMID 26801560, Free PMC Article
  5. The budding yeast rRNA and ribosome biosynthesis (RRB) regulon contains over 200 genes. Wade CH, et al. Yeast, 2006 Mar. PMID 16544271

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-arginine omega-N monomethyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-arginine omega-N monomethyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-arginine methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
protein-arginine N-methyltransferase SFM1
NP_014664.1
  • SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    372798..373439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183440.1 → NP_014664.1  protein-arginine N-methyltransferase SFM1

    See identical proteins and their annotated locations for NP_014664.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W288, Q12314
    UniProtKB/TrEMBL
    A6ZNM6, B3LJ76, B5VRS4, C7GLF2, C8ZHY4, G2WMQ3, N1NWU1
    Conserved Domains (1) summary
    pfam04252
    Location:2 → 206
    RNA_Me_trans; Predicted SAM-dependent RNA methyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12314.1

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