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SGT2 Sgt2p [ Saccharomyces cerevisiae S288c ]

Gene ID: 854168, updated on 21-Mar-2017
Gene symbol
SGT2
Gene description
Sgt2p
Primary source
SGD:S000005533
Locus tag
YOR007C
Gene type
protein coding
RNA name
Sgt2p
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
See SGT2 in Map Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (338938..339978, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene DNA ligase (ATP) DNL4 Neighboring gene Tsr3p Neighboring gene tRNA Neighboring gene Slg1p

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
protein complex scaffold IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
posttranslational protein targeting to endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
response to heat IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
TRC complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
Names
Sgt2p
NP_014649.1
  • Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; similar to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    338938..339978 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183426.1NP_014649.1  TPA: Sgt2p [Saccharomyces cerevisiae S288c]

    See identical proteins and their annotated locations for NP_014649.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q12118
    Conserved Domains (5) summary
    smart00727
    Location:264298
    STI1; Heat shock chaperonin-binding motif
    sd00006
    Location:102130
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:136169
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:101167
    TPR_11; TPR repeat
    pfam16546
    Location:771
    SGTA_dimer; Homodimerization domain of SGTA
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