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DNL4 DNA ligase (ATP) DNL4 [ Saccharomyces cerevisiae S288c ]

Gene ID: 854166, updated on 10-Sep-2016
Gene symbol
DNL4
Gene description
DNA ligase (ATP) DNL4
Primary source
SGD:S000005531
Locus tag
YOR005C
Gene type
protein coding
RNA name
DNA ligase (ATP) DNL4
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LIG4
See DNL4 in Map Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (334509..337343, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene putative subtilisin-like protease YSP3 Neighboring gene rRNA-binding ribosome biosynthesis protein UTP23 Neighboring gene Tsr3p Neighboring gene Sgt2p

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Non-homologous end-joining, organism-specific biosystem (from KEGG)
    Non-homologous end-joining, organism-specific biosystemNonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX c...
  • Non-homologous end-joining, conserved biosystem (from KEGG)
    Non-homologous end-joining, conserved biosystemNonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX c...
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA ligase (ATP) activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA ligase (ATP) activity IEA
Inferred from Electronic Annotation
more info
 
DNA ligase (ATP) activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
DNA ligation involved in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
 
DNA ligation involved in DNA repair IEA
Inferred from Electronic Annotation
more info
 
DNA recombination IEA
Inferred from Electronic Annotation
more info
 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
DNA replication IEA
Inferred from Electronic Annotation
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
double-strand break repair via nonhomologous end joining IDA
Inferred from Direct Assay
more info
PubMed 
double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT lagging strand elongation IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleotide-excision repair, DNA gap filling IBA
Inferred from Biological aspect of Ancestor
more info
 
replicative cell aging IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
DNA ligase IV complex IPI
Inferred from Physical Interaction
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with nuclear chromatin IPI
Inferred from Physical Interaction
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Names
DNA ligase (ATP) DNL4
NP_014647.1
  • DNA ligase required for nonhomologous end-joining (NHEJ); forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth; mutations in human ortholog lead to ligase IV syndrome and Dubowitz syndrome

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    334509..337343 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183424.1NP_014647.1  DNA ligase (ATP) DNL4 [Saccharomyces cerevisiae S288c]

    See identical proteins and their annotated locations for NP_014647.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q08387
    Conserved Domains (5) summary
    cd07968
    Location:474635
    OBF_DNA_ligase_IV; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase IV is a DNA-binding module that is part of the catalytic core unit
    cd07903
    Location:244471
    Adenylation_DNA_ligase_IV; Adenylation domain of DNA Ligase IV
    TIGR00574
    Location:84717
    dnl1; DNA ligase I, ATP-dependent (dnl1)
    pfam00533
    Location:681767
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam04675
    Location:20207
    DNA_ligase_A_N; DNA ligase N terminus
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