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RPB11 DNA-directed RNA polymerase II core subunit RPB11 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854157, updated on 11-Jun-2025
Official Symbol
RPB11
Official Full Name
DNA-directed RNA polymerase II core subunit RPB11
Primary source
SGD:S000005365
Locus tag
YOL005C
See related
AllianceGenome:SGD:S000005365; FungiDB:YOL005C; VEuPathDB:YOL005C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to DNA-directed RNA polymerase activity and RNA-directed RNA polymerase activity. Involved in termination of RNA polymerase II transcription. Part of RNA polymerase II, core complex. Orthologous to human POLR2J (RNA polymerase II subunit J); POLR2J2 (RNA polymerase II subunit J2); and POLR2J3 (RNA polymerase II subunit J3). [provided by Alliance of Genome Resources, Jun 2025]
Orthologs
all
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See RPB11 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (315813..316175, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Csi2p Neighboring gene DNA topoisomerase 1 Neighboring gene transcriptional regulator SIN3 Neighboring gene palmitoyltransferase PFA4

Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Yeast RNA polymerase II subunit RPB11 is related to a subunit shared by RNA polymerase I and III. Woychik NA, et al. Gene Expr, 1993. PMID 8508029, Free PMC Article
  2. Host transcription factor Rpb11p affects tombusvirus replication and recombination via regulating the accumulation of viral replication proteins. Jaag HM, et al. Virology, 2007 Nov 25. PMID 17689583
  3. cis- and trans-Acting determinants of transcription termination by yeast RNA polymerase II. Steinmetz EJ, et al. Mol Cell Biol, 2006 Apr. PMID 16537912, Free PMC Article
  4. Distinct regions of RPB11 are required for heterodimerization with RPB3 in human and yeast RNA polymerase II. Benga WJ, et al. Nucleic Acids Res, 2005. PMID 15987790, Free PMC Article
  5. Transcriptomes of six mutants in the Sen1 pathway reveal combinatorial control of transcription termination across the Saccharomyces cerevisiae genome. Chen X, et al. PLoS Genet, 2017 Jun. PMID 28665995, Free PMC Article

See all (121) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An in vitro assay with the tombusvirus replicase indicated that Rpb11p affects TBSV replication and recombination only indirectly, via regulating p33 and p92(pol) levels.
    Title: Host transcription factor Rpb11p affects tombusvirus replication and recombination via regulating the accumulation of viral replication proteins.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA-directed RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to DNA-directed RNA polymerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-directed RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to RNA-directed RNA polymerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in termination of RNA polymerase II transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase II, core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase II, core complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RNA polymerase II, core complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
DNA-directed RNA polymerase II core subunit RPB11
NP_014638.1
  • RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    315813..316175 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183259.1 → NP_014638.1  TPA: DNA-directed RNA polymerase II core subunit RPB11 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014638.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W262, P38902
    UniProtKB/TrEMBL
    A6ZNK1, B3LJ51, C7GJV7, C8ZHW0, G2WMM6, N1P2V7
    Conserved Domains (1) summary
    cd06926
    Location:13 → 105
    RNAP_II_RPB11; RPB11 subunit of Eukaryotic RNA polymerase II
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38902.1

Gene LinkOut

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