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TOP1 DNA topoisomerase 1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854156, updated on 5-Aug-2018

Summary

Gene symbol
TOP1
Gene description
DNA topoisomerase 1
Primary source
SGD:S000005366
Locus tag
YOL006C
Gene type
protein coding
RNA name
DNA topoisomerase 1
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MAK1; MAK17

Genomic context

See TOP1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (313078..315387, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene ubiquinone-binding protein COQ10 Neighboring gene Csi2p Neighboring gene DNA-directed RNA polymerase II core subunit RPB11 Neighboring gene transcriptional regulator SIN3

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the TOP1 gene: The TOP1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA topoisomerase activity IEA
Inferred from Electronic Annotation
more info
 
DNA topoisomerase type I activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA topoisomerase type I activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA topoisomerase type I activity IEA
Inferred from Electronic Annotation
more info
 
DNA topoisomerase type I activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
isomerase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA strand elongation involved in DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA topological change IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA topological change IDA
Inferred from Direct Assay
more info
PubMed 
DNA topological change IEA
Inferred from Electronic Annotation
more info
 
DNA topological change IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin assembly or disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin silencing at rDNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic chromosome condensation IGI
Inferred from Genetic Interaction
more info
PubMed 
mitotic chromosome condensation IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear migration IGI
Inferred from Genetic Interaction
more info
PubMed 
nuclear migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitotic recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription elongation from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
chromosome IEA
Inferred from Electronic Annotation
more info
 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleolus IPI
Inferred from Physical Interaction
more info
PubMed 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
replication fork protection complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
replication fork protection complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA topoisomerase 1
NP_014637.1
  • Topoisomerase I; nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination; role in processing ribonucleoside monophosphates in genomic DNA into irreversible single-strand breaks; enzymatic activity and interaction with Nsr1p are negatively regulated by polyphosphorylation

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    313078..315387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183260.1NP_014637.1  TPA: DNA topoisomerase 1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014637.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P04786
    Conserved Domains (2) summary
    smart00435
    Location:292741
    TOPEUc; DNA Topoisomerase I (eukaryota)
    pfam02919
    Location:143361
    Topoisom_I_N; Eukaryotic DNA topoisomerase I, DNA binding fragment
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