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MDM12 ERMES complex subunit MDM12 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854153, updated on 9-Dec-2024

Summary

Official Symbol
MDM12
Official Full Name
ERMES complex subunit MDM12
Primary source
SGD:S000005369
Locus tag
YOL009C
See related
AllianceGenome:SGD:S000005369; FungiDB:YOL009C; VEuPathDB:YOL009C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to lipid transfer activity. Involved in several processes, including aminophospholipid transport; mitochondrion organization; and mitochondrion-endoplasmic reticulum membrane tethering. Located in mitochondrial outer membrane. Part of ERMES complex. Is active in mitochondria-associated endoplasmic reticulum membrane contact site. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See MDM12 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (309324..310139, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene lysophospholipase Neighboring gene rRNA-processing endoribonuclease Neighboring gene ubiquinone-binding protein COQ10 Neighboring gene Csi2p

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to lipid transfer activity IDA
Inferred from Direct Assay
more info
PubMed 
enables lipid transfer activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in aminophospholipid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intermembrane lipid transfer IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial genome maintenance IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial outer membrane translocase complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrion inheritance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrion organization IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrion-endoplasmic reticulum membrane tethering IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrion-endoplasmic reticulum membrane tethering IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peroxisome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phospholipid transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phospholipid transport IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein insertion into mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of ERMES complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ERMES complex IEA
Inferred from Electronic Annotation
more info
 
part_of ERMES complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondria-associated endoplasmic reticulum membrane contact site IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 
located_in plasma membrane HDA PubMed 

General protein information

Preferred Names
ERMES complex subunit MDM12
NP_014634.1
  • Mitochondrial outer membrane protein, ERMES complex subunit; required for transmission of mitochondria to daughter cells; required for mitophagy; may influence import and assembly of outer membrane beta-barrel proteins; localizes to mitochondria-ER contact sites; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    309324..310139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183263.1NP_014634.1  TPA: ERMES complex subunit MDM12 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014634.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZNJ7, B3LJ47, B5VRP4, D6W258, Q08064, Q92328
    UniProtKB/TrEMBL
    C7GJW1, C8ZHV6