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SDH5 succinate dehydrogenase assembly factor SDH5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854083, updated on 8-Oct-2017
Gene symbol
SDH5
Gene description
succinate dehydrogenase assembly factor SDH5
Primary source
SGD:S000005432
Locus tag
YOL071W
Gene type
protein coding
RNA name
succinate dehydrogenase assembly factor SDH5
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
EMI5
See SDH5 in Map Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (196507..196995)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Dsc2p Neighboring gene Thp1p Neighboring gene Nba1p Neighboring gene kinetochore-associated Ndc80 complex subunit NUF2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
ascospore formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrial electron transport, succinate to ubiquinone IBA
Inferred from Biological aspect of Ancestor
more info
 
mitochondrial respiratory chain complex II assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein-FAD linkage IEA
Inferred from Electronic Annotation
more info
 
protein-FAD linkage IMP
Inferred from Mutant Phenotype
more info
PubMed 
tricarboxylic acid cycle IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
Names
succinate dehydrogenase assembly factor SDH5
NP_014570.1
  • Protein required for flavinylation of Sdh1p; binds to Sdh1p and promotes FAD cofactor attachment, which is necessary for succinate dehydrogenase (SDH) complex assembly and activity; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    196507..196995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183326.1NP_014570.1  TPA: succinate dehydrogenase assembly factor SDH5 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014570.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q08230
    Conserved Domains (1) summary
    COG2938
    Location:52150
    SdhE; Succinate dehydrogenase flavin-adding protein, antitoxin component of the CptAB toxin-antitoxin module [Posttranslational modification, protein turnover, chaperones]
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