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NKD1 NKD inhibitor of WNT signaling pathway 1 [ Homo sapiens (human) ]

Gene ID: 85407, updated on 7-Jun-2020

Summary

Official Symbol
NKD1provided by HGNC
Official Full Name
NKD inhibitor of WNT signaling pathway 1provided by HGNC
Primary source
HGNC:HGNC:17045
See related
Ensembl:ENSG00000140807 MIM:607851
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Naked1
Summary
In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003]
Expression
Broad expression in lung (RPKM 3.1), brain (RPKM 2.1) and 20 other tissues See more
Orthologs

Genomic context

See NKD1 in Genome Data Viewer
Location:
16q12.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (50548396..50649249)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (50582241..50674771)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 13482 Neighboring gene long intergenic non-protein coding RNA 2178 Neighboring gene uncharacterized LOC101927272 Neighboring gene sorting nexin 20 Neighboring gene nucleotide binding oligomerization domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11639, FLJ13722, FLJ20269

Gene Ontology Provided by GOA

Function Evidence Code Pubs
PDZ domain binding IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
eye photoreceptor cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of convergent extension involved in axis elongation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of Wnt signaling pathway, planar cell polarity pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of non-canonical Wnt signaling pathway via JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell motility involved in somitogenic axis elongation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
somatic muscle development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
protein phosphatase type 2A complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein naked cuticle homolog 1
Names
Dvl-binding protein
NKD1, WNT signaling pathway inhibitor
naked cuticle homolog 1
naked cuticle-1
naked-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033119.5NP_149110.1  protein naked cuticle homolog 1

    See identical proteins and their annotated locations for NP_149110.1

    Status: VALIDATED

    Source sequence(s)
    AC007608, BC051288
    Consensus CDS
    CCDS10743.1
    UniProtKB/Swiss-Prot
    Q969G9
    Related
    ENSP00000268459.3, ENST00000268459.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    50548396..50649249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023804.1XP_016879293.1  protein naked cuticle homolog 1 isoform X1

  2. XM_011523399.2XP_011521701.1  protein naked cuticle homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_011521701.1

  3. XM_011523400.2XP_011521702.1  protein naked cuticle homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_011521702.1

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