DUF1 Duf1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: DUF1
Official Full Name: Duf1p
Primary source: SGD:S000005447
Locus tag: YOL087C
See related: AllianceGenome:SGD:S000005447; FungiDB:YOL087C; VEuPathDB:YOL087C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables ubiquitin binding activity. Predicted to be involved in double-strand break repair via homologous recombination. Located in cytoplasm. Orthologous to human WDR48 (WD repeat domain 48). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

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See DUF1 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (155287..158637, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Duf1p

NP_014554.1

Ubiquitin-binding hypothetical protein; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of human WDR48/UAF1, which is involved in regulating the Fanconi anemia pathway; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

155287..158637 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183341.1 → NP_014554.1 Duf1p

See identical proteins and their annotated locations for NP_014554.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1Y1, Q99247

UniProtKB/TrEMBL

N1NWC4

Conserved Domains (3) summary

sd00039
Location:165 → 207

7WD40; WD40 repeat [structural motif]

cd17041
Location:1018 → 1098

Ubl_WDR48; Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar proteins

cl29593
Location:10 → 296

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...