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MSH2 mismatch repair ATPase MSH2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854063, updated on 3-Feb-2019

Summary

Gene symbol
MSH2
Gene description
mismatch repair ATPase MSH2
Primary source
SGD:S000005450
Locus tag
YOL090W
Gene type
protein coding
RNA name
mismatch repair ATPase MSH2
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PMS5

Genomic context

See MSH2 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (147382..150276)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene cationic amino acid transporter Neighboring gene Spo21p Neighboring gene Hal9p Neighboring gene protein disulfide isomerase MPD2

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the MSH2 gene: The MSH2 gene is conserved in human, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to DNA insertion or deletion binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA-dependent ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to Y-form DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-strand/single-strand DNA junction binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to four-way junction DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
four-way junction DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to guanine/thymine mispair binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to guanine/thymine mispair binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to heteroduplex DNA loop binding IDA
Inferred from Direct Assay
more info
PubMed 
mismatched DNA binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to single base insertion or deletion binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to single base insertion or deletion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to single thymine insertion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
DNA recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
chromatin silencing at silent mating-type cassette IGI
Inferred from Genetic Interaction
more info
PubMed 
interstrand cross-link repair IGI
Inferred from Genetic Interaction
more info
PubMed 
maintenance of DNA repeat elements IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
meiotic gene conversion IMP
Inferred from Mutant Phenotype
more info
PubMed 
meiotic mismatch repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mismatch repair IEA
Inferred from Electronic Annotation
more info
 
mismatch repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postreplication repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
removal of nonhomologous ends IGI
Inferred from Genetic Interaction
more info
PubMed 
removal of nonhomologous ends IMP
Inferred from Mutant Phenotype
more info
PubMed 
replication fork arrest IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
MutSalpha complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MutSalpha complex IPI
Inferred from Physical Interaction
more info
PubMed 
MutSbeta complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MutSbeta complex IPI
Inferred from Physical Interaction
more info
PubMed 
mismatch repair complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mismatch repair complex IEA
Inferred from Electronic Annotation
more info
 
nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mismatch repair ATPase MSH2
NP_014551.1
  • Protein that binds to DNA mismatches; forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    147382..150276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183344.1NP_014551.1  TPA: mismatch repair ATPase MSH2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014551.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P25847
    Conserved Domains (6) summary
    cd03285
    Location:652880
    ABC_MSH2_euk; ATP-binding cassette domain of eukaryotic MutS2 homolog
    COG0249
    Location:11929
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
    pfam01624
    Location:19128
    MutS_I; MutS domain I
    pfam05188
    Location:151278
    MutS_II; MutS domain II
    pfam05190
    Location:491587
    MutS_IV; MutS family domain IV
    pfam05192
    Location:327425
    MutS_III; MutS domain III
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