YPQ1 cationic amino acid transporter [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: YPQ1
Official Full Name: cationic amino acid transporter
Primary source: SGD:S000005452
Locus tag: YOL092W
See related: AllianceGenome:SGD:S000005452; FungiDB:YOL092W; VEuPathDB:YOL092W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables basic amino acid transmembrane transporter activity. Involved in basic amino acid transmembrane export from vacuole. Located in fungal-type vacuole membrane. Orthologous to human SLC66A1 (solute carrier family 66 member 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

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See YPQ1 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (144204..145130)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ypq1p is thus involved in transport of amino acids into vacuoles
Title: Loss of ATP-dependent lysine uptake in the vacuolar membrane vesicles of Saccharomyces cerevisiae ypq1∆ mutant.
Results show that Ypq1 is selectively sorted and degraded in the vacuolar lumen following lysine withdrawal after ubiquitination.
Title: Ubiquitin-dependent lysosomal membrane protein sorting and degradation.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-lysine transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables basic amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables basic amino acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables basic amino acid transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within L-lysine transmembrane export from vacuole	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within L-lysine transmembrane export from vacuole	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-lysine transmembrane import into vacuole	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in basic amino acid transmembrane export from vacuole	IBA Inferred from Biological aspect of Ancestor more info
involved_in basic amino acid transmembrane export from vacuole	IEA Inferred from Electronic Annotation more info
involved_in basic amino acid transmembrane export from vacuole	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in basic amino acid transmembrane import into vacuole	IEA Inferred from Electronic Annotation more info
involved_in intracellular amino acid homeostasis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
located_in fungal-type vacuole membrane	HDA more info	PubMed
is_active_in fungal-type vacuole membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in fungal-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
located_in fungal-type vacuole membrane	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	EXP Inferred from Experiment more info	PubMed
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cationic amino acid transporter

NP_014549.1

Vacuolar membrane transporter for lysine; exporter necessary for lysine mobilization from the vacuole under conditions of lysine starvation and for rapid exchange between the vacuole and cytosol during active growth; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; YPQ1 has a paralog, RTC2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

144204..145130

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183346.1 → NP_014549.1 cationic amino acid transporter

See identical proteins and their annotated locations for NP_014549.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1X6, Q12010

UniProtKB/TrEMBL

B3LIX1

Conserved Domains (2) summary

pfam04193
Location:211 → 271

PQ-loop; PQ loop repeat

cl09326
Location:137 → 308

MATE_like; Multidrug and toxic compound extrusion family and similar proteins