U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

WRS1 tryptophan--tRNA ligase WRS1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854056, updated on 2-Nov-2024

Summary

Official Symbol
WRS1
Official Full Name
tryptophan--tRNA ligase WRS1
Primary source
SGD:S000005457
Locus tag
YOL097C
See related
AllianceGenome:SGD:S000005457; FungiDB:YOL097C; VEuPathDB:YOL097C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HRE342
Summary
Enables sequence-specific mRNA binding activity and tryptophan-tRNA ligase activity. Predicted to be involved in tryptophanyl-tRNA aminoacylation. Located in cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 9. Orthologous to human WARS1 (tryptophanyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See WRS1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (136527..137825, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene hexaprenyldihydroxybenzoate methyltransferase Neighboring gene ATP-dependent 3'-5' DNA helicase

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables tryptophan-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tryptophan-tRNA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables tryptophan-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in translation IEA
Inferred from Electronic Annotation
more info
 
involved_in tryptophanyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tryptophanyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
 
involved_in tryptophanyl-tRNA aminoacylation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tryptophan--tRNA ligase WRS1
NP_014544.1
  • Cytoplasmic tryptophanyl-tRNA synthetase; aminoacylates tryptophanyl-tRNA; human homolog WARS can complement yeast null mutant

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    136527..137825 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183351.1NP_014544.1  TPA: tryptophan--tRNA ligase WRS1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014544.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1X1, E9P8Z9, Q12109
    UniProtKB/TrEMBL
    A6ZNB3, B3LIW6, B5VRF8, C8ZHL8, G2WMD8, N1NX56
    Conserved Domains (1) summary
    cl00015
    Location:25409
    nt_trans; nucleotidyl transferase superfamily