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PAP2 non-canonical poly(A) polymerase PAP2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854034, updated on 9-Jul-2017
Gene symbol
PAP2
Gene description
non-canonical poly(A) polymerase PAP2
Primary source
SGD:S000005475
Locus tag
YOL115W
Gene type
protein coding
RNA name
non-canonical poly(A) polymerase PAP2
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
TRF4
See PAP2 in Map Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (101475..103229)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Rri2p Neighboring gene Msn1p Neighboring gene Pth4p Neighboring gene putative serine/threonine protein kinase SKM1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • RNA degradation, organism-specific biosystem (from KEGG)
    RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
  • RNA degradation, conserved biosystem (from KEGG)
    RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
  • TRAMP complex, organism-specific biosystem (from KEGG)
    TRAMP complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
  • TRAMP complex, conserved biosystem (from KEGG)
    TRAMP complex, conserved biosystemStructural complex; Genetic information processing; RNA processing
Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by GO

Function Evidence Code Pubs
5'-deoxyribose-5-phosphate lyase activity IDA
Inferred from Direct Assay
more info
PubMed 
5'-deoxyribose-5-phosphate lyase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to ATP-dependent 3'-5' RNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
polynucleotide adenylyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
polynucleotide adenylyltransferase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
polynucleotide adenylyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
polynucleotide adenylyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
U4 snRNA 3'-end processing IGI
Inferred from Genetic Interaction
more info
PubMed 
U4 snRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
base-excision repair IGI
Inferred from Genetic Interaction
more info
PubMed 
base-excision repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
histone mRNA catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
meiotic DNA double-strand break formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
ncRNA polyadenylation IDA
Inferred from Direct Assay
more info
PubMed 
ncRNA polyadenylation IGI
Inferred from Genetic Interaction
more info
PubMed 
ncRNA polyadenylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of DNA recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear mRNA surveillance of mRNA 3'-end processing IGI
Inferred from Genetic Interaction
more info
PubMed 
nuclear polyadenylation-dependent CUT catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
nuclear polyadenylation-dependent CUT catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear polyadenylation-dependent antisense transcript catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear polyadenylation-dependent mRNA catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
nuclear polyadenylation-dependent rRNA catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
nuclear polyadenylation-dependent rRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear polyadenylation-dependent snRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear polyadenylation-dependent snoRNA catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
nuclear polyadenylation-dependent snoRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear polyadenylation-dependent tRNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
nuclear polyadenylation-dependent tRNA catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
nuclear polyadenylation-dependent tRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
polyadenylation-dependent mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
polyadenylation-dependent snoRNA 3'-end processing IGI
Inferred from Genetic Interaction
more info
PubMed 
snoRNA polyadenylation IGI
Inferred from Genetic Interaction
more info
PubMed 
tRNA modification IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
TRAMP complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Names
non-canonical poly(A) polymerase PAP2
NP_014526.1
  • Non-canonical poly(A) polymerase; involved in nuclear RNA degradation as a component of TRAMP; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; required for mRNA surveillance and maintenance of genome integrity, serving as a link between RNA and DNA metabolism; overlapping but non-redundant functions with Trf5p; relocalizes to cytosol in response to hypoxia

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    101475..103229
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183369.1NP_014526.1  TPA: non-canonical poly(A) polymerase PAP2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014526.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P53632
    Conserved Domains (3) summary
    cd05402
    Location:199311
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    COG5260
    Location:116584
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
    pfam03828
    Location:371431
    PAP_assoc; Cid1 family poly A polymerase
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