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MCH4 Mch4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854030, updated on 3-May-2025
Official Symbol
MCH4
Official Full Name
Mch4p
Primary source
SGD:S000005479
Locus tag
YOL119C
See related
AllianceGenome:SGD:S000005479; FungiDB:YOL119C; VEuPathDB:YOL119C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in riboflavin transport. Predicted to act upstream of or within transmembrane transport. Located in fungal-type vacuole membrane. Human ortholog(s) of this gene implicated in cataract 47. Orthologous to several human genes including SLC16A10 (solute carrier family 16 member 10); SLC16A11 (solute carrier family 16 member 11); and SLC16A12 (solute carrier family 16 member 12). [provided by Alliance of Genome Resources, May 2025]
Orthologs
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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (94856..96361, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S19A Neighboring gene ribosomal 60S subunit protein L18A Neighboring gene uncharacterized protein Neighboring gene Rri2p

Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Disruption and basic functional analysis of six novel ORFs of chromosome XV from Saccharomyces cerevisiae. Lafuente MJ, et al. Yeast, 1999 Jul. PMID 10407273
  2. The putative monocarboxylate permeases of the yeast Saccharomyces cerevisiae do not transport monocarboxylic acids across the plasma membrane. Makuc J, et al. Yeast, 2001 Sep 15. PMID 11536335
  3. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Halestrap AP, et al. Biochem J, 1999 Oct 15. PMID 10510291, Free PMC Article
  4. The proline-dependent transcription factor Put3 regulates the expression of the riboflavin transporter MCH5 in Saccharomyces cerevisiae. Spitzner A, et al. Genetics, 2008 Dec. PMID 18940788, Free PMC Article
  5. A CRISPR/Cas9-based exploration into the elusive mechanism for lactate export in Saccharomyces cerevisiae. Mans R, et al. FEMS Yeast Res, 2017 Dec 1. PMID 29145596

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in riboflavin transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
Mch4p
NP_014522.1
  • Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    94856..96361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183373.1 → NP_014522.1  TPA: Mch4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014522.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1U9, Q08268
    UniProtKB/TrEMBL
    A6ZN92, B3LIU7, C7GSR8, G2WMB8, N1NW76
    Conserved Domains (1) summary
    cd17352
    Location:96 → 490
    MFS_MCT_SLC16; Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08268.1

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