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RPS19A 40S ribosomal protein eS19 RPS19A [ Saccharomyces cerevisiae S288C ]

Gene ID: 854028, updated on 15-Mar-2026
Official Symbol
RPS19A
Official Full Name
40S ribosomal protein eS19 RPS19A
Primary source
SGD:S000005481
Locus tag
YOL121C
See related
AllianceGenome:SGD:S000005481; FungiDB:YOL121C; VEuPathDB:YOL121C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
A structural constituent of ribosome. Involved in ribosomal small subunit biogenesis and ribosomal subunit export from nucleus. Part of cytosolic small ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia and Diamond-Blackfan anemia 1. Orthologous to human RPS19 (ribosomal protein S19). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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Location:
chromosome: XV
Exon count:
2
Sequence:
Chromosome: XV; NC_001147.6 (92026..92850, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Hrp1p Neighboring gene divalent metal ion transporter SMF1 Neighboring gene 60S ribosomal protein eL18 RPL18A Neighboring gene Mch4p

Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Genetic evidence for 18S rRNA binding and an Rps19p assembly function of yeast nucleolar protein Nep1p. Buchhaupt M, et al. Mol Genet Genomics, 2006 Sep. PMID 16721597
  2. Genetic mapping of two pairs of linked ribosomal protein genes in Saccharomyces cerevisiae. Papciak SM, et al. Curr Genet, 1987. PMID 3329973
  3. Molecular basis of Diamond-Blackfan anemia: structure and function analysis of RPS19. Gregory LA, et al. Nucleic Acids Res, 2007. PMID 17726054, Free PMC Article
  4. Rapid identification of chemical genetic interactions in Saccharomyces cerevisiae. Dilworth D, et al. J Vis Exp, 2015 Apr 5. PMID 25867090, Free PMC Article
  5. Specific Role for Yeast Homologs of the Diamond Blackfan Anemia-associated Rps19 Protein in Ribosome Synthesis. Léger-Silvestre I, et al. J Biol Chem, 2005 Nov 18. PMID 16159874

See all (92) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal small subunit biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal small subunit biogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ribosomal small subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal subunit export from nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal subunit export from nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ribosomal subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
40S ribosomal protein eS19 RPS19A
NP_014520.1
  • Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19A has a paralog, RPS19B, that arose from the whole genome duplication

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    92026..92850 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183375.1 → NP_014520.1  40S ribosomal protein eS19 RPS19A

    See identical proteins and their annotated locations for NP_014520.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1U7, P07280
    UniProtKB/TrEMBL
    A6ZN90, B3LIU5, C7GUZ8, C8ZHJ5, G2WMB6, N1NYU7
    Conserved Domains (1) summary
    pfam01090
    Location:5 → 142
    Ribosomal_S19e; Ribosomal protein S19e
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07280.2

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