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AGPS alkylglycerone phosphate synthase [ Homo sapiens (human) ]

Gene ID: 8540, updated on 15-Apr-2019

Summary

Official Symbol
AGPSprovided by HGNC
Official Full Name
alkylglycerone phosphate synthaseprovided by HGNC
Primary source
HGNC:HGNC:327
See related
Ensembl:ENSG00000018510 MIM:603051
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADAS; ADPS; RCDP3; ADAP-S; ADHAPS; ALDHPSY
Summary
This gene is a member of the FAD-binding oxidoreductase/transferase type 4 family. It encodes a protein that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetonephosphate (DHAP) is converted to alkyl-DHAP by the addition of a long chain alcohol and the removal of a long-chain acid anion. The protein is localized to the inner aspect of the peroxisomal membrane and requires FAD as a cofactor. Mutations in this gene have been associated with rhizomelic chondrodysplasia punctata, type 3 and Zellweger syndrome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in colon (RPKM 7.8), endometrium (RPKM 6.7) and 25 other tissues See more
Orthologs

Genomic context

See AGPS in Genome Data Viewer
Location:
2q31.2
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (177392743..177543836)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (178257471..178408564)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene nuclear factor, erythroid 2 like 2 Neighboring gene microRNA 3128 Neighboring gene uncharacterized LOC100130691 Neighboring gene microRNA 6512 Neighboring gene uncharacterized LOC105373762 Neighboring gene tetratricopeptide repeat domain 30B Neighboring gene tetratricopeptide repeat domain 30A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr is identified to have a physical interaction with alkylglycerone phosphate synthase (AGPS) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
capsid gag The interaction of HIV-1 CA with human cellular alkylglycerone phosphate synthase protein (AGPS) is identified by yeast two-hybrid screen PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Ether lipid metabolism, organism-specific biosystem (from KEGG)
    Ether lipid metabolism, organism-specific biosystem
    Ether lipid metabolism
  • Ether lipid metabolism, conserved biosystem (from KEGG)
    Ether lipid metabolism, conserved biosystem
    Ether lipid metabolism
  • Glycerophospholipid Biosynthetic Pathway, organism-specific biosystem (from WikiPathways)
    Glycerophospholipid Biosynthetic Pathway, organism-specific biosystemGlycerophospholipids or phosphoglycerides, in which the hydrophobic regions are composed of two fatty acids joined to glycerol; and sphingolipids, in which a single fatty acid is joined to a fatty am...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Peroxisomal lipid metabolism, organism-specific biosystem (from REACTOME)
    Peroxisomal lipid metabolism, organism-specific biosystemIn humans, the catabolism of phytanate, pristanate, and very long chain fatty acids as well as the first four steps of the biosynthesis of plasmalogens are catalyzed by peroxisomal enzymes. Defects i...
  • Peroxisome, organism-specific biosystem (from KEGG)
    Peroxisome, organism-specific biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
  • Peroxisome, conserved biosystem (from KEGG)
    Peroxisome, conserved biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
  • Plasmalogen biosynthesis, organism-specific biosystem (from REACTOME)
    Plasmalogen biosynthesis, organism-specific biosystem1-Acylglycerol-3-phosphate is synthesized from dihydroxyacetone phosphate, an acyl CoA molecule and NADPH + H+ in four reactions catalyzed by peroxisomal enzymes, either in the matrix of the organell...
  • Triacylglyceride Synthesis, organism-specific biosystem (from WikiPathways)
    Triacylglyceride Synthesis, organism-specific biosystem
    Triacylglyceride Synthesis

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ99755, DKFZp762O2215

Gene Ontology Provided by GOA

Function Evidence Code Pubs
FAD binding ISS
Inferred from Sequence or Structural Similarity
more info
 
alkylglycerone-phosphate synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ether lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
ether lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
ether lipid biosynthetic process TAS
Traceable Author Statement
more info
 
lipid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
protein targeting to peroxisome TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
mitochondrion HDA PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
peroxisomal matrix TAS
Traceable Author Statement
more info
 
peroxisomal membrane HDA PubMed 
peroxisome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
alkyldihydroxyacetonephosphate synthase, peroxisomal
Names
aging-associated gene 5 protein
aging-associated protein 5
alkyl-DHAP synthase
NP_003650.1
XP_011510343.1
XP_011510344.1
XP_011510345.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008968.1 RefSeqGene

    Range
    5001..156094
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003659.4NP_003650.1  alkyldihydroxyacetonephosphate synthase, peroxisomal precursor

    See identical proteins and their annotated locations for NP_003650.1

    Status: REVIEWED

    Source sequence(s)
    AA832354, AC073834, AK314259
    Consensus CDS
    CCDS2275.1
    UniProtKB/Swiss-Prot
    O00116
    Related
    ENSP00000264167.4, ENST00000264167.9
    Conserved Domains (3) summary
    COG0277
    Location:200652
    GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
    pfam01565
    Location:206347
    FAD_binding_4; FAD binding domain
    pfam02913
    Location:385657
    FAD-oxidase_C; FAD linked oxidases, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    177392743..177543836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512041.2XP_011510343.1  alkyldihydroxyacetonephosphate synthase, peroxisomal isoform X1

    See identical proteins and their annotated locations for XP_011510343.1

    UniProtKB/TrEMBL
    B7Z3Q4
    Related
    ENSP00000490844.1, ENST00000637633.1
    Conserved Domains (1) summary
    COG0277
    Location:110562
    GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
  2. XM_011512042.1XP_011510344.1  alkyldihydroxyacetonephosphate synthase, peroxisomal isoform X1

    See identical proteins and their annotated locations for XP_011510344.1

    UniProtKB/TrEMBL
    B7Z3Q4
    Conserved Domains (1) summary
    COG0277
    Location:110562
    GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
  3. XM_011512043.2XP_011510345.1  alkyldihydroxyacetonephosphate synthase, peroxisomal isoform X2

    Conserved Domains (3) summary
    COG0277
    Location:10407
    GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
    pfam01565
    Location:11102
    FAD_binding_4; FAD binding domain
    pfam02913
    Location:140412
    FAD-oxidase_C; FAD linked oxidases, C-terminal domain

RNA

  1. XR_001739007.2 RNA Sequence

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