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AGPS alkylglycerone phosphate synthase [ Homo sapiens (human) ]

Gene ID: 8540, updated on 6-Sep-2022

Summary

Official Symbol
AGPSprovided by HGNC
Official Full Name
alkylglycerone phosphate synthaseprovided by HGNC
Primary source
HGNC:HGNC:327
See related
Ensembl:ENSG00000018510 MIM:603051; AllianceGenome:HGNC:327
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADAS; ADPS; RCDP3; ADAP-S; ADHAPS; ALDHPSY
Summary
This gene is a member of the FAD-binding oxidoreductase/transferase type 4 family. It encodes a protein that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetonephosphate (DHAP) is converted to alkyl-DHAP by the addition of a long chain alcohol and the removal of a long-chain acid anion. The protein is localized to the inner aspect of the peroxisomal membrane and requires FAD as a cofactor. Mutations in this gene have been associated with rhizomelic chondrodysplasia punctata, type 3 and Zellweger syndrome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in colon (RPKM 7.8), endometrium (RPKM 6.7) and 25 other tissues See more
Orthologs
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Genomic context

See AGPS in Genome Data Viewer
Location:
2q31.2
Exon count:
22
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (177392773..177543834)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (177875047..178026109)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (178257501..178408562)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Putative uncharacterized protein FLJ44553 Neighboring gene small nucleolar RNA U13 Neighboring gene H3 histone pseudogene 7 Neighboring gene Sharpr-MPRA regulatory region 2066 Neighboring gene Sharpr-MPRA regulatory region 14377 Neighboring gene uncharacterized LOC105373762 Neighboring gene tetratricopeptide repeat domain 30B Neighboring gene uncharacterized LOC124906098

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr is identified to have a physical interaction with alkylglycerone phosphate synthase (AGPS) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
capsid gag The interaction of HIV-1 CA with human cellular alkylglycerone phosphate synthase protein (AGPS) is identified by yeast two-hybrid screen PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ99755, DKFZp762O2215

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables FAD binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables alkylglycerone-phosphate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables alkylglycerone-phosphate synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ether lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in ether lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within lipid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane HDA PubMed 
located_in mitochondrion HDA PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in peroxisomal matrix TAS
Traceable Author Statement
more info
 
located_in peroxisomal membrane HDA PubMed 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
alkyldihydroxyacetonephosphate synthase, peroxisomal
Names
aging-associated gene 5 protein
aging-associated protein 5
alkyl-DHAP synthase
NP_003650.1
XP_011510343.1
XP_047302060.1
XP_047302061.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008968.1 RefSeqGene

    Range
    5031..156092
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003659.4NP_003650.1  alkyldihydroxyacetonephosphate synthase, peroxisomal precursor

    See identical proteins and their annotated locations for NP_003650.1

    Status: REVIEWED

    Source sequence(s)
    AA832354, AC073834, AK314259
    Consensus CDS
    CCDS2275.1
    UniProtKB/Swiss-Prot
    O00116, Q2TU35
    Related
    ENSP00000264167.4, ENST00000264167.11
    Conserved Domains (3) summary
    COG0277
    Location:200652
    GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
    pfam01565
    Location:206347
    FAD_binding_4; FAD binding domain
    pfam02913
    Location:385657
    FAD-oxidase_C; FAD linked oxidases, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    177392773..177543834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047446105.1XP_047302061.1  alkyldihydroxyacetonephosphate synthase, peroxisomal isoform X2

    Related
    ENSP00000505620.1, ENST00000681565.1
  2. XM_011512041.3XP_011510343.1  alkyldihydroxyacetonephosphate synthase, peroxisomal isoform X1

    See identical proteins and their annotated locations for XP_011510343.1

    UniProtKB/TrEMBL
    B7Z3Q4
    Related
    ENSP00000505342.1, ENST00000681449.1
    Conserved Domains (1) summary
    COG0277
    Location:110562
    GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
  3. XM_047446104.1XP_047302060.1  alkyldihydroxyacetonephosphate synthase, peroxisomal isoform X1

    UniProtKB/TrEMBL
    B7Z3Q4
    Related
    ENSP00000506484.1, ENST00000679478.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    177875047..178026109
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)