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VBA5 basic amino acid transporter [ Saccharomyces cerevisiae S288C ]

Gene ID: 853980, updated on 6-Jul-2026
Official Symbol
VBA5
Official Full Name
basic amino acid transporter
Primary source
SGD:S000001813
Locus tag
YKR105C
See related
AllianceGenome:SGD:S000001813; FungiDB:YKR105C; VEuPathDB:YKR105C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable transmembrane transporter activity. Involved in L-arginine transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See VBA5 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (658716..660464, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene putative multidrug transporter NFT1 Neighboring gene uncharacterized protein Neighboring gene glutathione exchanger

Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Vba5p, a novel plasma membrane protein involved in amino acid uptake and drug sensitivity in Saccharomyces cerevisiae. Shimazu M, et al. Biosci Biotechnol Biochem, 2012. PMID 23047103
  2. Emergence of species-specific transporters during evolution of the hemiascomycete phylum. De Hertogh B, et al. Genetics, 2006 Feb. PMID 16118182, Free PMC Article
  3. A family of basic amino acid transporters of the vacuolar membrane from Saccharomyces cerevisiae. Shimazu M, et al. J Biol Chem, 2005 Feb 11. PMID 15572352
  4. Iterative carotenogenic screens identify combinations of yeast gene deletions that enhance sclareol production. Trikka FA, et al. Microb Cell Fact, 2015 Apr 24. PMID 25903744, Free PMC Article
  5. Variation in gene duplicates with low synonymous divergence in Saccharomyces cerevisiae relative to Caenorhabditis elegans. Katju V, et al. Genome Biol, 2009. PMID 19594930, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-arginine transmembrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in L-arginine transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
basic amino acid transporter
NP_013031.3
  • Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; VBA5 has a paralog, VBA3, that arose from a segmental duplication

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    658716..660464 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179895.3 → NP_013031.3  basic amino acid transporter

    See identical proteins and their annotated locations for NP_013031.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXG6, P36172
    UniProtKB/TrEMBL
    B3LU18
    Conserved Domains (1) summary
    cd17502
    Location:43 → 493
    MFS_Azr1_MDR_like; Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36172.1

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