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MLP1 Mlp1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853970, updated on 11-Jan-2018
Gene symbol
MLP1
Gene description
Mlp1p
Primary source
SGD:S000001803
Locus tag
YKR095W
Gene type
protein coding
RNA name
Mlp1p
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MPL1
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (619805..625432)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Ptr2p Neighboring gene ubiquitin-ribosomal 60S subunit protein L40B fusion protein Neighboring gene chromatin DNA-binding EKC/KEOPS complex subunit PCC1 Neighboring gene Esl2p

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
    MAPK Signaling Pathway, organism-specific biosystemThe MAPK/ERK pathway is a signal transduction pathway that couples intracellular responses to the binding of growth factors to cell surface receptors. In many cell types, activation of this pathway p...
  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pore activity IBA
Inferred from Biological aspect of Ancestor
more info
 
ribonucleoprotein complex binding IGI
Inferred from Genetic Interaction
more info
PubMed 
ribonucleoprotein complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
mRNA transport IEA
Inferred from Electronic Annotation
more info
 
mitotic spindle assembly checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of protein import into nucleus during spindle assembly checkpoint IGI
Inferred from Genetic Interaction
more info
PubMed 
nuclear retention of unspliced pre-mRNA at the site of transcription IGI
Inferred from Genetic Interaction
more info
PubMed 
nuclear retention of unspliced pre-mRNA at the site of transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
poly(A)+ mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
protein import into nucleus IGI
Inferred from Genetic Interaction
more info
PubMed 
protein localization to nuclear pore IMP
Inferred from Mutant Phenotype
more info
PubMed 
telomere tethering at nuclear periphery IGI
Inferred from Genetic Interaction
more info
PubMed 
transcriptional activation by promoter-terminator looping IMP
Inferred from Mutant Phenotype
more info
PubMed 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane ISM
Inferred from Sequence Model
more info
PubMed 
colocalizes_with intracellular ribonucleoprotein complex IPI
Inferred from Physical Interaction
more info
PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pore nuclear basket IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with spindle pole body IDA
Inferred from Direct Assay
more info
PubMed 
Names
Mlp1p
NP_013021.1
  • Myosin-like protein associated with the nuclear envelope; nuclear basket protein that connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs; MLP1 has a paralog, MLP2, that arose from the whole genome duplication

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    619805..625432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179885.1NP_013021.1  TPA: Mlp1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013021.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q02455
    Conserved Domains (3) summary
    COG1196
    Location:2141087
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06273
    Location:13961475
    eIF-4B; Plant specific eukaryotic initiation factor 4B
    pfam07926
    Location:9991125
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
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