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RGS8 regulator of G protein signaling 8 [ Homo sapiens (human) ]

Gene ID: 85397, updated on 19-Jun-2019

Summary

Official Symbol
RGS8provided by HGNC
Official Full Name
regulator of G protein signaling 8provided by HGNC
Primary source
HGNC:HGNC:16810
See related
Ensembl:ENSG00000135824 MIM:607189
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. [provided by RefSeq, Jul 2008]
Expression
Biased expression in thyroid (RPKM 1.7), brain (RPKM 1.0) and 3 other tissues See more
Orthologs

Genomic context

See RGS8 in Genome Data Viewer
Location:
1q25.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (182641814..182753293, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (182613036..182653502, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene regulator of G protein signaling 16 Neighboring gene long intergenic non-protein coding RNA 1686 Neighboring gene long intergenic non-protein coding RNA 1688 Neighboring gene NSE4 homolog A, SMC5-SMC6 complex component pseudogene Neighboring gene N-acetylneuraminate pyruvate lyase Neighboring gene uncharacterized LOC647070 Neighboring gene DExH-box helicase 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119067, MGC119068, MGC119069

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled acetylcholine receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of dopamine receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
extrinsic component of cytoplasmic side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal cell body membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
regulator of G-protein signaling 8
Names
regulator of G-protein signalling 8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102450.2NP_001095920.1  regulator of G-protein signaling 8 isoform 2

    See identical proteins and their annotated locations for NP_001095920.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an additional exon in the 5' region, which results in an alternate 5' coding sequence, as compared to variant 1. The resulting isoform (2) has a shorter and alternate N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK057753, AL353778, BC103867, BG195915, BM681011, R37101
    Consensus CDS
    CCDS41443.1
    UniProtKB/Swiss-Prot
    P57771
    Related
    ENSP00000356528.4, ENST00000367557.8
    Conserved Domains (1) summary
    cd08711
    Location:46170
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
  2. NM_001369564.2NP_001356493.1  regulator of G-protein signaling 8 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL353778
  3. NM_033345.3NP_203131.1  regulator of G-protein signaling 8 isoform 1

    See identical proteins and their annotated locations for NP_203131.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AI209102, AK057753, AL353778, BC069677, BG195915, BM681011, BX954018, R37101
    Consensus CDS
    CCDS1349.1
    UniProtKB/Swiss-Prot
    P57771
    Related
    ENSP00000258302.4, ENST00000258302.8
    Conserved Domains (1) summary
    cd08711
    Location:64188
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    182641814..182753293 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510089.3XP_011508391.1  regulator of G-protein signaling 8 isoform X1

    See identical proteins and their annotated locations for XP_011508391.1

    UniProtKB/Swiss-Prot
    P57771
    Conserved Domains (1) summary
    cd08711
    Location:64188
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
  2. XM_017002634.1XP_016858123.1  regulator of G-protein signaling 8 isoform X1

    UniProtKB/Swiss-Prot
    P57771
    Conserved Domains (1) summary
    cd08711
    Location:64188
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
  3. XM_017002632.1XP_016858121.1  regulator of G-protein signaling 8 isoform X1

    UniProtKB/Swiss-Prot
    P57771
    Conserved Domains (1) summary
    cd08711
    Location:64188
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
  4. XM_017002631.2XP_016858120.1  regulator of G-protein signaling 8 isoform X1

    UniProtKB/Swiss-Prot
    P57771
    Conserved Domains (1) summary
    cd08711
    Location:64188
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
  5. XM_017002633.1XP_016858122.1  regulator of G-protein signaling 8 isoform X1

    UniProtKB/Swiss-Prot
    P57771
    Conserved Domains (1) summary
    cd08711
    Location:64188
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
  6. XM_017002635.1XP_016858124.1  regulator of G-protein signaling 8 isoform X2

    UniProtKB/Swiss-Prot
    P57771
    Conserved Domains (1) summary
    cd08711
    Location:46170
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
  7. XM_011510090.2XP_011508392.1  regulator of G-protein signaling 8 isoform X2

    See identical proteins and their annotated locations for XP_011508392.1

    UniProtKB/Swiss-Prot
    P57771
    Conserved Domains (1) summary
    cd08711
    Location:46170
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
  8. XM_017002637.2XP_016858126.1  regulator of G-protein signaling 8 isoform X2

    UniProtKB/Swiss-Prot
    P57771
    Conserved Domains (1) summary
    cd08711
    Location:46170
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
  9. XM_011510091.3XP_011508393.1  regulator of G-protein signaling 8 isoform X3

    See identical proteins and their annotated locations for XP_011508393.1

    Conserved Domains (1) summary
    cd08711
    Location:44168
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
  10. XM_005245555.4XP_005245612.1  regulator of G-protein signaling 8 isoform X2

    See identical proteins and their annotated locations for XP_005245612.1

    UniProtKB/Swiss-Prot
    P57771
    Related
    ENSP00000426289.1, ENST00000483095.6
    Conserved Domains (1) summary
    cd08711
    Location:46170
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
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