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PRP16 DEAH-box RNA helicase PRP16 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853961, updated on 8-May-2022

Summary

Gene symbol
PRP16
Gene description
DEAH-box RNA helicase PRP16
Primary source
SGD:S000001794
Locus tag
YKR086W
See related
AllianceGenome:SGD:S000001794
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PRP23; RNA16
Summary
Enables ATP-dependent activity, acting on RNA. Contributes to second spliceosomal transesterification activity. Involved in RNA exon ligation; generation of catalytic spliceosome for second transesterification step; and snRNA modification. Part of U2-type catalytic step 2 spliceosome. Used to study retinitis pigmentosa. Human ortholog(s) of this gene implicated in retinitis pigmentosa 84. Orthologous to human DHX38 (DEAH-box helicase 38). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See PRP16 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (599857..603072)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene ribosome dissociation factor GTPase HBS1 Neighboring gene mitochondrial 54S ribosomal protein YmL20 Neighboring gene metalloendopeptidase Neighboring gene Tvp38p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the PRP16 gene: The PRP16 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent activity, acting on RNA IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to second spliceosomal transesterification activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA exon ligation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in generation of catalytic spliceosome for second transesterification step IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in snRNA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in snRNA modification IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of U2-type catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
DEAH-box RNA helicase PRP16
NP_013012.3
  • DEAH-box RNA helicase; involved in the second catalytic step of splicing and in exon ligation; exhibits ATP-dependent RNA unwinding activity; mediates the release of Yju2p and Cwc25p in the second step; in the absence of ATP, stabilizes the binding of Cwc25p to the spliceosome in the first catalytic step; missense mutation in human ortholog DHX38 associated with early-onset retinitis pigmentosa

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    599857..603072
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179876.3NP_013012.3  TPA: DEAH-box RNA helicase PRP16 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013012.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P15938
    Conserved Domains (1) summary
    COG1643
    Location:3191071
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]