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ECM4 S-glutathionyl-(chloro)hydroquinone reductase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853951, updated on 12-Aug-2025
Official Symbol
ECM4
Official Full Name
S-glutathionyl-(chloro)hydroquinone reductase
Primary source
SGD:S000001784
Locus tag
YKR076W
See related
AllianceGenome:SGD:S000001784; FungiDB:YKR076W; VEuPathDB:YKR076W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GTO2
Summary
Enables glutathione transferase activity. Involved in glutathione metabolic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See ECM4 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (582283..583395)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Aim29p Neighboring gene uncharacterized protein Neighboring gene Msa2p Neighboring gene sorting nexin family protein

Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Crystal Structure of Saccharomyces cerevisiae ECM4, a Xi-Class Glutathione Transferase that Reacts with Glutathionyl-(hydro)quinones. Schwartz M, et al. PLoS One, 2016. PMID 27736955, Free PMC Article
  2. Differentiating mechanisms of toxicity using global gene expression analysis in Saccharomyces cerevisiae. Caba E, et al. Mutat Res, 2005 Aug 4. PMID 15878181
  3. Evolutionary relationships between Saccharomyces cerevisiae and other fungal species as determined from genome comparisons. Herrero E. Rev Iberoam Micol, 2005 Dec. PMID 16499414
  4. Cytotoxicity mechanism of two naphthoquinones (menadione and plumbagin) in Saccharomyces cerevisiae. Castro FA, et al. PLoS One, 2008. PMID 19098979, Free PMC Article
  5. Saccharomyces cerevisiae cells have three Omega class glutathione S-transferases acting as 1-Cys thiol transferases. Garcerá A, et al. Biochem J, 2006 Sep 1. PMID 16709151, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ScECM4 possessed a tremendously elongated loop between strand beta2 and helix alpha2 involved in the dimer interface, two more spiral turns in helix alpha5 that make it 45 A long and an additional helix alpha5' with two helical turns.
    Title: Crystal Structure of Saccharomyces cerevisiae ECM4, a Xi-Class Glutathione Transferase that Reacts with Glutathionyl-(hydro)quinones.
  2. act as 1-Cys thiol transferases
    Title: Saccharomyces cerevisiae cells have three Omega class glutathione S-transferases acting as 1-Cys thiol transferases.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables glutathione dehydrogenase (ascorbate) activity IEA
Inferred from Electronic Annotation
more info
  
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in glutathione metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
S-glutathionyl-(chloro)hydroquinone reductase
NP_013002.3
  • S-glutathionyl-(chloro)hydroquinone reductase (GS-HQR); glutathione transferase involved in cell-surface biosynthesis and architecture; catalyzes glutathione (GSH)-dependent reduction of GS-trichloro-p-hydroquinone to trichloro-p-hydroquinone; expression upregulated upon exposure to genotoxic agents, such as methyl methanesulfonate, cisplatin and bleomycin; not an essential gene; similar to YGR154C; green fluorescent protein (GFP)-fusion protein localizes to cytoplasm

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    582283..583395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179866.3 → NP_013002.3  TPA: S-glutathionyl-(chloro)hydroquinone reductase

    See identical proteins and their annotated locations for NP_013002.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXD6, P36156
    UniProtKB/TrEMBL
    A0A0L8VLX5, A7A035, B3LRF0, C7GXD4, C8ZCN7, G2WIA3
    Conserved Domains (1) summary
    COG0435
    Location:1 → 370
    ECM4; Glutathionyl-hydroquinone reductase [Energy production and conversion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36156.1

Gene LinkOut

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