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YSR3 sphinganine kinase YSR3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853927, updated on 9-Dec-2024

Summary

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Official Symbol
YSR3
Official Full Name
sphinganine kinase YSR3
Primary source
SGD:S000001761
Locus tag
YKR053C
See related
AllianceGenome:SGD:S000001761; FungiDB:YKR053C; VEuPathDB:YKR053C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LBP2
Summary
Enables sphingosine-1-phosphate phosphatase activity. Involved in phospholipid dephosphorylation and sphingolipid biosynthetic process. Located in endoplasmic reticulum. Orthologous to human SGPP1 (sphingosine-1-phosphate phosphatase 1) and SGPP2 (sphingosine-1-phosphate phosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See YSR3 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (534067..535281, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Hfl1p Neighboring gene Fe(2+) transporter Neighboring gene dynein heavy chain Neighboring gene Rho family GTPase RHO4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase. Mao C, et al. J Biol Chem, 1997 Nov 7. PMID 9353337
  2. The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses. Mao C, et al. Biochem J, 1999 Sep 15. PMID 10477278, Free PMC Article
  3. Yeast sphingosine-1-phosphate phosphatases: assay, expression, deletion, purification, and cellular localization by GFP tagging. Mao C, et al. Methods Enzymol, 2000. PMID 10563329
  4. Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response. Mandala SM, et al. Proc Natl Acad Sci U S A, 1998 Jan 6. PMID 9419344, Free PMC Article
  5. Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast. Watanabe R, et al. J Biol Chem, 2002 Dec 20. PMID 12393888

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables dihydrosphingosine-1-phosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables sphingosine-1-phosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sphingosine-1-phosphate phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sphingolipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sphinganine kinase YSR3
NP_012979.3
  • Dihydrosphingosine 1-phosphate phosphatase; membrane protein involved in sphingolipid metabolism; YSR3 has a paralog, LCB3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    534067..535281 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179843.3 → NP_012979.3  TPA: sphinganine kinase YSR3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012979.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXB4, P23501
    UniProtKB/TrEMBL
    A7A013, C7GNL2, C8ZCL7, N1P2Q5
    Conserved Domains (1) summary
    cd03388
    Location:77 → 231
    PAP2_SPPase1; PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23501.2

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